The Translational Medicinal and Biological Chemistry Laboratory headed by Prof. Ana Martinez, at the Margarita Salas Center for Biological Research (CIB-CSIC) has officially been approved as the new EU-OPENSCREEN medicinal chemistry partner site in Spain.
EU-OPENSCREEN is a distributed European Research Infrastructure in the field of chemical biology. EU-OPENSCREEN aims at increasing collaboration in the field of high-throughput screening and medicinal chemistry and enabling access to otherwise not available resources such as a unique compound collection and an open-access database.
The Translational Medicinal and Biological Chemistry research group has high experience in molecular modeling and chemoinformatics, organic synthesis, biological screening, ADMETox properties optimization, and business management. Projects running at the Translational Medicinal and Biological Chemistry Laboratory increase the knowledge on innovative targets with clear therapeutic potential for unmet diseases such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, trypanosiomasis, and allow the discovery of new drug candidates for their treatment.
In this regard, the Translational Medicinal and Biological Chemistry Laboratory is a leader in Spain in the research and development of new drugs for the treatment of neurological and neglected diseases.
The group has developed an in-house chemical library (called MBC library) containing over 2000 compounds with privileged scaffolds, which is continuously growing and extensively used in the directed biological and computational screening programs. Their research is applied with a high content of translational research and designed from the early stages of drug discovery to proof of efficacy in representative animal models. Scientific collaborations and technology transfer to companies in the pharmaceutical sector are key tasks.
EU-OPENSCREEN website: link.
CSIC Press Release (in Spanish): link.