Molecular Biology of the Chromosomes

Head of lab

Jorge Bernardo Schvartzman Blinder

We are interested in all the biological processes where DNA is involved: replication, transcription, repair and recombination, how are they regulated and how they alter and are affected by epigenetic factors such as DNA topology and chromatin organization.

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a) Initiation, Elongation, Blockage, Termination and Topology of DNA Replication.

Head:

Jorge Bernardo Schvartzman Blinder

b) Identificaction and Cloning of Genes Involved in Erythroid Differentiation.

Head:

Dora Beatriz Krimer Smunis

c) Replication Fork Barriers and DNA Instability.

Head:

Pablo Hernández Valenzuela

Staff Scientists
Dora Beatriz Krimer Smunis
Jorge Bernardo Schvartzman Blinder
Pablo Hernández Valenzuela

Technician
Alicia Rodríguez Bernabé

Predoctoral Students
Alicia Castán García
David Álvarez Melo
Iván Hernández Martínez
Vanesa Fernández Calleja

Junior PI
Jesus A. Carballo

Master Students
Ana Paramio Lorente

Fernández-Calleja V., Hernández P., Schvartzman J.B., García-de-Lacoba, Krimer D.B [2017]. Differential gene expression analysis by RNA-seq reveals the importance of actin cytoskeletal proteins in Friend Leukemia cells. PeerJ (doi/10.7717/peerj.3432)

Castán A., Hernández P., Krimer D.B.,Schvartzman J.B. [2017]. The abundance of Fob1 modulates de efficiency of rRFBs to stall replication forks. Nucleic Acids Res (doi: 10.1093/nar/gkx655)

Cebrián J, Castán A, Martínez V, Parra C, Kadomatsu-Hermosa MJ, Fernández-Nestosa MJ, Schaerer C, Hernández P, Krimer DB, Schvartzman JB [2015]. Direct evidence for the formation of precatenanes during DNA replication. Journal Biol Chem 290: 13725-13735.

Penedos A, Johnson AL, Strong E, Goldman AS, Carballo JA, Cha RS [2015]. Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1. PLoS One 10(7):e0134297. doi: 10.1371/journal.pone.0134297

Cebrián J, Monturus E, Martínez-Robles M-L, Hernández P, Krimer DB, Schvartzman JB [2014]. Topoisomerase 2 Is Dispensable for the Replication and Segregation of Small Yeast Artificial Chromosomes (YACs). PLoS ONE 9(8): e104995.

Cebrián J, Kadomatsu-Hermosa MJ, Castán A, Martínez V, Parra, C, Fernández-Nestosa MJ, Schaerer, C, Martínez-Robles M-L, Hernández P, Krimer DB, Stasiak A, Schvartzman JB [2014]. Electrophoretic mobility of supercoiled, catenated and knotted DNA molecules. Nucleic Acids Res (doi: 10.1093/nar/gku1255).

Schvartzman JB, Martínez-Robles ML, Hernández P, Krimer DB [2013]. The benefit of DNA supercoiling during replication. Biochemical Society Transactions 41: 646-651

Fernández-Nestosa MJ, Monturus E, Sánchez Z, Torres F, Fernández A, Fraga M, Hernández P, Schvartzman JB, Krimer DB [2013]. DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation. SpringerPlus 2, 392 DOI:10.1186/2193-1801-2-392

Schvartzman JB, Martínez-Robles ML, Hernández P, Krimer DB [2013]. Plasmid DNA topology assayed by two-dimensional agarose gel electrophoresis. In Methods Mol Biol 1054, DNA Electrophoresis: Methods and Protocols (Svetlana Makovets, ed.) Springer Science Business Media, New York. DOI 10.1007/978-1-62703-565-1_7

Newnham L, Jordan PW, Carballo JA, Newcombe S, Hoffmann E [2013]. Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis. PLoS One 8(12):e83982. doi:10.1371/journal.pone.0083982

All Publications

- MINECO, BFU2011-22489 (2012-2014)

- AECID, AP / 038170 / 11

- CSIC, I - COOP0009

- ENTRANCE

- LAB MEMBERS

- FORMER STUDENTS: What they accomplished with us and where are they now?

- MONTHLY PROGRAM

- JOURNAL CLUB

- PROTOCOLS AND LINKS

- 2D GELS

Group Leader/s

Jorge Bernardo Schvartzman Blinder

intro

Research lines

a) Initiation, Elongation, Blockage, Termination and Topology of DNA Replication.

b) Identificaction and Cloning of Genes Involved in Erythroid Differentiation.

c) Replication Fork Barriers and DNA Instability.

Members

Publications

Fernández-Calleja V., Hernández P., Schvartzman J.B., García-de-Lacoba, Krimer D.B [2017]. Differential gene expression analysis by RNA-seq reveals the importance of actin cytoskeletal proteins in Friend Leukemia cells. PeerJ (doi/10.7717/peerj.3432)

Castán A., Hernández P., Krimer D.B.,Schvartzman J.B. [2017]. The abundance of Fob1 modulates de efficiency of rRFBs to stall replication forks. Nucleic Acids Res (doi: 10.1093/nar/gkx655)

Cebrián J, Castán A, Martínez V, Parra C, Kadomatsu-Hermosa MJ, Fernández-Nestosa MJ, Schaerer C, Hernández P, Krimer DB, Schvartzman JB [2015]. Direct evidence for the formation of precatenanes during DNA replication. Journal Biol Chem 290: 13725-13735.

Cebrián J, Monturus E, Martínez-Robles M-L, Hernández P, Krimer DB, Schvartzman JB [2014]. Topoisomerase 2 Is Dispensable for the Replication and Segregation of Small Yeast Artificial Chromosomes (YACs). PLoS ONE 9(8): e104995.

Schvartzman JB, Martínez-Robles ML, Hernández P, Krimer DB [2013]. The benefit of DNA supercoiling during replication. Biochemical Society Transactions 41: 646-651

Fernández-Nestosa MJ, Monturus E, Sánchez Z, Torres F, Fernández A, Fraga M, Hernández P, Schvartzman JB, Krimer DB [2013]. DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation. SpringerPlus 2, 392 DOI:10.1186/2193-1801-2-392

Newnham L, Jordan PW, Carballo JA, Newcombe S, Hoffmann E [2013]. Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis. PLoS One 8(12):e83982. doi:10.1371/journal.pone.0083982

Funding

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