Group Leader/s

 

intro

The main interest of our laboratory is the search for new tumoral biomarkers for the molecular diagnostics and the characterization of new therapeutic targets, the study of the molecular mechanisms involved in the epithelial-mesenchyma transition, tumoral progression and metastasis in colorectal cancer. Our strategy is based on the application of advanced proteomic tools, such as two-dimensional electrophoresis in combination with DIGE, mass-spectrometry and the use of protein microarrays, to the study of the alterations in proteins and antibodies that occur in plasma samples, tissues and/or tumoral cell lines.

 

Bartolomé RA, S Torres, S Isern de Val, B Escudero-Paniagua, E Calviño, J Teixidó and JI Casal  [2017]. VE-cadherin promotes metastasis and consitutes a potential therapeutic target in melanoma and breast cancer. Oncotarget. 8, 215-227

Villar-Vázquez R, Guillermo Padilla, María Jesús Fernández-Aceñero, Adolfo Suárez, Eduardo Fuente, Carlos Pastor, Miguel Calero, Rodrigo Barderas and J. Ignacio Casal  [2016]. Development of a novel multiplex beads-based assay for autoantibody detection for colorectal cancer diagnosis. Proteomics. 16(8), 1280-90

García-Palmero I, S Torres, RA Bartolomé, A Peláez-García, MJ Larriba, M Lopez-Lucendo, C Peña, B Escudero-Paniagua, A Muñoz and JI Casal  [2016]. Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI) . Oncogene. 40, 5224-36. doi: 10.1038/onc.2016.57

Li, C., Wang X, Casal I., Wang J, Li P, Zhang W, Xu E, Lai M and Zhang H.  [2016]. Growth Differentiation Factor 15 (GDF15) is a Promising Diagnostic and Prognostic Biomarker in Colorectal Cancer. J. Cell. Mol. Med. DOI: 10.1111/jcmm.12830

Soler M, M. C Estevez, R Villar-Vazquez, JI Casal and LM Lechuga  [2016]. Label-free Nanoplasmonic Sensing of Tumor-Associated Autoantibodies for Early Diagnosis of Colorectal Cancer. Anl. Chim. Acta. 930: 31-8

Alba-Castellón L., R Olivera, A Mestre, R Peña, M Herrera, F Bonilla, J Baulida, JI Casal, C Peña, and A García de Herreros.  [2016]. Snail1-dependent activation of cancer-associated fibroblast controls collective tumor cell invasion and metastasis. Cancer Res, 76, 6205-17

Fernández-Aceñero MJ, S Torres, I Garcia-Palmero, C Díaz del Arco and J.I. Casal  [2016]. Prognostic role of tissue transglutaminase 2 in colon carcinoma. Virchows Arch. 469, 611-19

Vialas V , N Colomé-Calls, JAbian, K Aloria, G Alvarez-Llamas , O Antúnez , JM Arizmendi, M Azkargorta, S Barceló-Batllori , MG Barderas , F Blanco, JI Casal, V Casas, C de la Torre, E Chicano-Gálvez, F Elortza , G Espadas, JM Estanyol, J Fernandez-Irigoyen, P Fernandez-Puente, MJ Fidalgo, M Fuentes, M Gay, C Gil, A Hainard, ML Hernaez, N Ibarrola, AT Kopylov, A Lario, JA Lopez, M López-Lucendo, M Marcilla, A Marina-Ramírez, G Marko-Varga, L Martín, MI Mora, E Morato-López, J Muñoz, M A Odena, E de Oliveira, I Orera, I Ortea, C Pasquarello, KB Ray, M Rezeli, I Ruppen, E Sabidó, MM Sanchez del Pino, J Sancho, E Santamaría, J Vazquez, M Vilaseca, F Vivanco, JJ Walters, VG Zgoda, FJ Corrales, F Canals, A Paradela  [2016]. A multicentric study to evaluate the use of relative retention times in targeted proteomics. J. Proteomics. 152, 138-149

de Barrios O, B Győrffy, MJ Fernández-Aceñero, E Sánchez-Tilló, L. Sanchez-Moral, L. Siles, A. Esteve-Arenys, G. Rouge, JI Casal, DS Darling, A Castells and A Postigo  [2016]. ZEB1-induced tumorigenesis requires senescence inhibtion via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. Gut. doi:10.1136/gutjnl-2015-310838

Peláez-García A, Barderas R, Batlle R, Viñas-Castells R, Bartolomé RA, Torres S, Mendes M, Lopez-Lucendo M, Mazzolini R, Bonilla F, García de Herreros A, Casal JI  [2015]. A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nr2f6 and IL-17 to inhibit adipocyte differentiation. Mol Cell Proteomics. 14, 303-15. doi:10.1074/mcp.M114.045328

 

Funding

 

 

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