Group Leader/s

 

intro

T lymphocyte activation and differentiation induced by antigen and costimulatory molecules is mediated by signals that are essential to mount immune responses against pathogens and cancer, or to develop autoimmune diseases. Our interest is focused on the possible use of class I PI3 kinases and the costimulatory signals mediated by CD28 family molecules like ICOS (Inducible Costimulator, CD278) and their ligands as targets in immunotherapy.

 

 

Members

Team Image
 

Acosta YY, Montes-Casado M, Aragoneses-Fenoll L, Dianzani U, Portolés P, Rojo JM  [2014]. Suppression of CD4+ T lymphocyte activation “in vitro” and experimental encephalomyelitis “in vivo” by the phosphatidyl inositol 3-kinase inhibitor PIK-75. International Journal of Immunopathology and Pharmacology 27: 53-67 (PMID: 24674679)

 

Funding

Grant PI13/01809: “ICOS, ICOS ligand and Class IA PI3-kinases as targets in immunotherapy". Acción Estratégica en Salud, IS Carlos III (01/2014-09/2017)

Grant PI10/00650: “ICOS signaling in costimulation and adhesion, conditioned deficiency in T lymphocyte lineages, and impact in autoimmune inflammatory diseases” AES, IS Carlos III (01/2011-12/2013)

Grant PI070620: “Mechanisms of activation by ICOS (CD278): Pro- and anti-inflammatory effects in Experimental Allergic Encephalitis” Fondo de Investigación Sanitaria, IS Carlos III (11/2007-11/2010)

Grant SAF2004-06852, "Inducible Costimulator (ICOS): Integration of costimulatory pathways in T lymphocytes and specific signaling" MEC, Programa Nacional de Salud y Farmacia (12/2004-12/2007).

Grant BMC2001-2177, “Variability mechanisms of “invariant” CD3ε chains of T lymphocyte TCR/CD3 complex: Changes in complex structure and activation signals" MCyT, Programa Nacional de Promoción General del Conocimiento (12/ 2001-12/2004)

 

More info

PhD Thesis

Acosta Ampudia YY (2013) "Association of Class IA PI3-kinase subunits to ICOS (CD278) and relevance to costimulation" PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.

Bello R (2007) "Immunological and functional analysis of CD3ε chains of the TCR/CD3 complex". PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.

Sánchez, A (2006) "Analysis of costimulatory effect of CD46 (MCP) in CD4+ T lymphocytes. Interaction with pathogens and search of potential ligands". PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.