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intro

Endoglin and ALK1 are components of the TGF-beta receptor complex in endothelial cells that are involved in vascular physiopathology. Mutations in endoglin or ALK1 (ACVRL1) genes give rise to the Hereditary Hemorrhagic Telangiectasia (HHT), a dominant autosomic vascular dysplasia. Endoglin and ALK1 regulate angiogenesis and vascular homeostasis, and a soluble form of endoglin has a pathogenic role in preeclampsia.

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