Our group has as main research interest the study of the metabolic and regulatory networks that control the bacterial metabolism of toxic compounds and/or biowaste, many of which are major environmental pollutants. The cell signaling circuits and the cognate resistance mechanisms involved in the bacterial adaptation to the stress caused by the toxic compounds are also under study. To this end, we carry out classic approaches of physiology, biochemistry and molecular biology, in combination with modern omic techniques and in silico metabolic models, to achieve an integrative and systems biology view. The acquired knowledge is also used to design, through systems metabolic engineering, recombinant microorganisms as biofactories for the conversion of contaminants/waste into added value products. The development of sustainable technologies to fix CO2, and to remove and revalorize contaminants and biowaste is a priority within the framework of a circular bio-economy.
Durante-Rodríguez G, Gómez-Álvarez H, Nogales J, Carmona M, Díaz E . One-Component Systems that Regulate the Expression of Degradation Pathways for Aromatic Compounds. In book: Handbook of Hydrocarbon and Lipid Microbiology, Publisher: Springer International Publishing, Editors: Tino Krell, pp.1-39
Zamarro MT, Barragán MJL, Carmona M, García JL, Díaz E . Engineering a bzd cassette for the anaerobic bioconversion of aromatic compounds. Microbial Biotechnology 10:1418-1425
Martínez I, El-Said Mohamed M, Santos VE, García JL, García-Ochoa F, Díaz E . Metabolic and process engineering for biodesulfurization in Gram-negative bacteria. J Biotechnol 262:47-55
Durante-Rodríguez G, Mancheño JM, Díaz E, Carmona M. . Refactoring the lambda phage lytic/lysogenic decision with a synthetic regulator. Microbiology Open. 5:575-581
Fernández-Llamosas H, Castro L, Blázquez ML, Díaz E, Carmona M . Biosynthesis of selenium nanoparticles by Azoarcus sp. CIB. Microb Cell Fact 15:109. doi: 10.1186/s12934-016-0510-y
Martín-Moldes Z, Blázquez B, Baraquet C, Harwood CS, Zamarro MT, Díaz E. . Degradation of cyclic diguanosine monophosphate by a hybrid two-component protein protects Azoarcus sp. strain CIB from toluene toxicity. Proc Natl Acad Sci U S A. 113:13174-13179.
Zamarro MT, Martín-Moldes Z, Díaz E. . The ICEXTD of Azoarcus sp. CIB, an integrative and conjugative element with aerobic and anaerobic catabolic properties. Environ Microbiol. 18:5018-5031
Martínez I, El-Said Mohamed M, Rozas D, García JL, Díaz E. . Engineering synthetic bacterial consortia for enhanced desulfurization and revalorization of oil sulfur compounds. Metab. Eng. 35: 46–54.
Martín-Moldes Z, Zamarro MT, del Cerro C, Valencia A, Gómez MJ, Arcas A, Udaondo Z, García JL, Nogales J, Carmona M, Díaz E. . Whole-genome analysis of Azoarcus sp. strain CIB provides genetic insights to its different lifestyles and predicts novel metabolic features. Syst. Appl. Microbiol. 38: 462-471.
- EU, QLK3-2000-00170 (2000-2003)
- CICYT, BIO2000-1076 (2000-2003)
- CICYT, GEN2001-4698-C05-02 (2003-2005)
- CAM, 07M/0076/2002 (2003-2004)
- CICYT, BIO2003-01482 (2004-2006)
- CICYT, VEM2003-20075-C02-02 (2004-2006)
- CAM, AMB-259-0505 (2006-2010)
- CSIC 2004 2 0E 073
- CICYT, BIO2006-05957 (2006-2009)
- CICYT, EU-SYSMO, GEN2006-27750-C5-3-E(2007-2010)- CICYT
- Consolider CSD2007-00005 (2008-2013)
- CICYT BIO2009-10438 (2009-2013)
- Aramco Overseas Company BV Contract No. 6600029601 (2012-2014)
- CICYT BIO2012-39501 (2013-2015)
- FP7-KBBE 311815 (2012-2016)
- MINECO PCIN-2014-113
- CAM S2013/ABI-2783
- Ramón-Areces Fundation (XVII CN)
- CICYT BIO2016-79736-R (2017-2019)