Group Leader/s

 

intro

Main research focus in our lab is the characterization of cell adhesion, migration and invasion in response to chemokines, both under physiological and pathological conditions.

 

Benito-Jardón L, Díaz-Martínez M, Arellano-Sánchez N, Vaquero-Morales P, Esparis-Ogando A and Teixidó J  [2019]. Resistance to MAPK inhibitors in melanoma involves activation of the IGF-1R-MEK5-Erk5 pathway. Cancer Res. In press. doi: 10.1158/0008-5472.CAN-18-2762

Redondo-Muñoz J, García-Pardo A and Teixidó J  [2019]. Molecular players in hematological tumor cell trafficking. Frontiers in Immunol. 10:156

Díaz-Martínez M, Benito-Jardón L, Alonso L, Koetz-Ploch L, Hernando E, Teixido J.  [2018]. miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma. Cancer Research, 78: 1017-1030.

M Martínez-Moreno, M Leiva, N Aguilera-Montilla, S Sevilla-Movilla, S I de Val, N Arellano-Sánchez, N C Gutiérrez, R Maldonado, J Martínez-López, I Buño, J A García-Marco, P Sánchez-Mateos, A Hidalgo, A García-Pardo and J Teixidó  [2016]. In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins. 2016. Leukemia, 30, 861-872

Gutiérrez-González A, Martínez-Moreno M, Samaniego R, Arellano-Sánchez N, Salinas-Muñoz L, Relloso M, Valeri A, Martínez-López J, Corbí ÁL, Hidalgo A, García-Pardo Á, Teixidó J, Sánchez-Mateos P.  [2016]. Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myeloma. Blood. 128: 2241-2252

Sosa-Costa A, Isern de Val S, Sevilla-Movilla S, Borgman KJ, Manzo C, Teixidó J, Garcia-Parajo MF.  [2016]. Lateral Mobility and Nanoscale Spatial Arrangement of Chemokine-activated α4β1 Integrins on T Cells. J Biol Chem. 291: 21053-21062

Dios-Esponera A, Isern de Val S, Sevilla-Movilla S, García-Verdugo R, García-Bernal D, Arellano-Sánchez N, Cabañas C, Teixidó J.  [2015]. Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T lymphocyte adhesion mediated by integrin α4β1. Mol Biol Cell. 2015 Jul 22. pii: mbc.E14-07-1246. PMID: 26202465

García-Bernal D, Redondo-Muñoz J, Dios-Esponera A, Chèvre R, Bailón E, Garayoa M, Arellano-Sánchez N, Gutiérrez NC, Hidalgo A, García-Pardo A, Teixidó J  [2013]. Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function. J Pathol 229: 36-48

Coló GP, Hernández-Varas P, Lock J, Bartolomé RA, Arellano-Sánchez N, Strömblad S, Teixidó J.  [2012]. Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway. J Cell Sci. 2012 Nov 15;125(Pt 22):5338-52. doi: 10.1242/jcs.105270. Epub 2012 Sep 3. PMID: 22946047

García-Bernal D, Parmo-Cabañas M, Dios-Esponera A, Samaniego R, Hernán-P de la Ossa D and Teixidó J  [2009]. Chemokine-Induced Zap70 Kinase-Mediated Dissociation of the Vav1-Talin Complex Activates alpha4beta1 Integrin for T Cell Adhesion. Immunity 31 (6): 953-64 (DOI 10.1016/j.immuni.2009.09.021)

 

Funding

- Imaging, genomics and proteomics analyses of B cell hematological tumor progression

S2010/BMD-2314. Biomedicina. Comunidad de Madrid. 2012-2016. IP: Joaquin Teixido Calvo

- Spanish Network of Cooperative Research in Cancer

Ministry of Health RD12/0036/0061 (2012-2017) - Institute of Health Carlos III (ISCIII) cofunded by the Fondo Europeo de Desarrollo Regional (FEDER). IP: Joaquin Teixido Calvo

- Characterization of molecular pathways controlling cell motility in leukocyte trafficking and tumor cell invasion

SAF2014-53059-R: 2015-2017. IP: Joaquin Teixidó

- Characterization of molecular mechanisms involved in migration, survival and resistance to chemotherapy in multiple myeloma and melanoma. 

SAF2017-85146-R: 2018-2020. IP: Joaquin Teixidó Calvo

 

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