Group Leader/s

 

intro

Main research focus in our lab is the characterization of cell adhesion, migration and invasion in response to chemokines, both under physiological and pathological conditions.

 

Members

Staff Scientists
Joaquín Teixidó Calvo
Technical Staff
Nohemí Arellano Sánchez
Predoctoral Students
Lucia Benito Jardon
Team Image
 

Benito-Jardón L, Díaz-Martínez M, Arellano-Sánchez N, Vaquero-Morales P, Esparis-Ogando A and Teixidó J  [2019]. Resistance to MAPK inhibitors in melanoma involves activation of the IGF-1R-MEK5-Erk5 pathway. Cancer Res. In press. doi: 10.1158/0008-5472.CAN-18-2762

Redondo-Muñoz J, García-Pardo A and Teixidó J  [2019]. Molecular players in hematological tumor cell trafficking. Frontiers in Immunol. 10:156

Díaz-Martínez M, Benito-Jardón L, Alonso L, Koetz-Ploch L, Hernando E, Teixido J.  [2018]. miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma. Cancer Research, 78: 1017-1030.

M Martínez-Moreno, M Leiva, N Aguilera-Montilla, S Sevilla-Movilla, S I de Val, N Arellano-Sánchez, N C Gutiérrez, R Maldonado, J Martínez-López, I Buño, J A García-Marco, P Sánchez-Mateos, A Hidalgo, A García-Pardo and J Teixidó  [2016]. In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins. 2016. Leukemia, 30, 861-872

Gutiérrez-González A, Martínez-Moreno M, Samaniego R, Arellano-Sánchez N, Salinas-Muñoz L, Relloso M, Valeri A, Martínez-López J, Corbí ÁL, Hidalgo A, García-Pardo Á, Teixidó J, Sánchez-Mateos P.  [2016]. Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myeloma. Blood. 128: 2241-2252

Sosa-Costa A, Isern de Val S, Sevilla-Movilla S, Borgman KJ, Manzo C, Teixidó J, Garcia-Parajo MF.  [2016]. Lateral Mobility and Nanoscale Spatial Arrangement of Chemokine-activated α4β1 Integrins on T Cells. J Biol Chem. 291: 21053-21062

Dios-Esponera A, Isern de Val S, Sevilla-Movilla S, García-Verdugo R, García-Bernal D, Arellano-Sánchez N, Cabañas C, Teixidó J.  [2015]. Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T lymphocyte adhesion mediated by integrin α4β1. Mol Biol Cell. 2015 Jul 22. pii: mbc.E14-07-1246. PMID: 26202465

García-Bernal D, Redondo-Muñoz J, Dios-Esponera A, Chèvre R, Bailón E, Garayoa M, Arellano-Sánchez N, Gutiérrez NC, Hidalgo A, García-Pardo A, Teixidó J  [2013]. Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function. J Pathol 229: 36-48

Coló GP, Hernández-Varas P, Lock J, Bartolomé RA, Arellano-Sánchez N, Strömblad S, Teixidó J.  [2012]. Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway. J Cell Sci. 2012 Nov 15;125(Pt 22):5338-52. doi: 10.1242/jcs.105270. Epub 2012 Sep 3. PMID: 22946047

García-Bernal D, Parmo-Cabañas M, Dios-Esponera A, Samaniego R, Hernán-P de la Ossa D and Teixidó J  [2009]. Chemokine-Induced Zap70 Kinase-Mediated Dissociation of the Vav1-Talin Complex Activates alpha4beta1 Integrin for T Cell Adhesion. Immunity 31 (6): 953-64 (DOI 10.1016/j.immuni.2009.09.021)

 

Funding

- Imaging, genomics and proteomics analyses of B cell hematological tumor progression

S2010/BMD-2314. Biomedicina. Comunidad de Madrid. 2012-2016. IP: Joaquin Teixido Calvo

- Spanish Network of Cooperative Research in Cancer

Ministry of Health RD12/0036/0061 (2012-2017) - Institute of Health Carlos III (ISCIII) cofunded by the Fondo Europeo de Desarrollo Regional (FEDER). IP: Joaquin Teixido Calvo

- Characterization of molecular pathways controlling cell motility in leukocyte trafficking and tumor cell invasion

SAF2014-53059-R: 2015-2017. IP: Joaquin Teixidó

- Characterization of molecular mechanisms involved in migration, survival and resistance to chemotherapy in multiple myeloma and melanoma. 

SAF2017-85146-R: 2018-2020. IP: Joaquin Teixidó Calvo

 

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