Group Leader/s

 

intro

The main interest of our laboratory is the search for new tumoral biomarkers for the molecular diagnostics and the characterization of new therapeutic targets, the study of the molecular mechanisms involved in the epithelial-mesenchyma transition, tumoral progression and metastasis in colorectal cancer. Our strategy is based on the application of advanced proteomic tools, such as two-dimensional electrophoresis in combination with DIGE, mass-spectrometry and the use of protein microarrays, to the study of the alterations in proteins and antibodies that occur in plasma samples, tissues and/or tumoral cell lines.

 

Bartolomé RA, S Torres, S Isern de Val, B Escudero-Paniagua, E Calviño, J Teixidó and JI Casal  [2017]. VE-cadherin promotes metastasis and consitutes a potential therapeutic target in melanoma and breast cancer. Oncotarget. 8, 215-227

Vialas V , N Colomé-Calls, JAbian, K Aloria, G Alvarez-Llamas , O Antúnez , JM Arizmendi, M Azkargorta, S Barceló-Batllori , MG Barderas , F Blanco, JI Casal, V Casas, C de la Torre, E Chicano-Gálvez, F Elortza , G Espadas, JM Estanyol, J Fernandez-Irigoyen, P Fernandez-Puente, MJ Fidalgo, M Fuentes, M Gay, C Gil, A Hainard, ML Hernaez, N Ibarrola, AT Kopylov, A Lario, JA Lopez, M López-Lucendo, M Marcilla, A Marina-Ramírez, G Marko-Varga, L Martín, MI Mora, E Morato-López, J Muñoz, M A Odena, E de Oliveira, I Orera, I Ortea, C Pasquarello, KB Ray, M Rezeli, I Ruppen, E Sabidó, MM Sanchez del Pino, J Sancho, E Santamaría, J Vazquez, M Vilaseca, F Vivanco, JJ Walters, VG Zgoda, FJ Corrales, F Canals, A Paradela  [2016]. A multicentric study to evaluate the use of relative retention times in targeted proteomics. J. Proteomics. 152, 138-149

Fernández-Aceñero MJ, S Torres, I Garcia-Palmero, C Díaz del Arco and J.I. Casal  [2016]. Prognostic role of tissue transglutaminase 2 in colon carcinoma. Virchows Arch. 469, 611-19

Alba-Castellón L., R Olivera, A Mestre, R Peña, M Herrera, F Bonilla, J Baulida, JI Casal, C Peña, and A García de Herreros.  [2016]. Snail1-dependent activation of cancer-associated fibroblast controls collective tumor cell invasion and metastasis. Cancer Res, 76, 6205-17

 

Funding

 

 

Fellowships and jobs

 

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