Group Leader/s



Endoglin and ALK1 are components of the TGF-beta receptor complex in endothelial cells that are involved in vascular physiopathology. Mutations in endoglin or ALK1 (ACVRL1) genes give rise to the Hereditary Hemorrhagic Telangiectasia (HHT), a dominant autosomic vascular dysplasia. Endoglin and ALK1 regulate angiogenesis and vascular homeostasis, and a soluble form of endoglin has a pathogenic role in preeclampsia.






More info

Currently no information is available