Group Leader/s

 

intro

During the last ten years, the research group led by Dr. Angel Luis Corbí and Dr. Miguel Vega Palacios (“Myeloid Cell Biology Laboratory”) has been actively involved in determining the molecular mechanisms underlying the acquisition of pro-inflammatory and anti-inflammatory effector functions by human macrophages. The most relevant achievements of the group in the last years include: 1) the demonstration of the intracellular signaling ability of the pathogen receptor DC-SIGN, and its involvement in the maintenance of an immunosuppressive environment in tumors; 2) the demonstration that MEK-ERK and p38MAPK exert opposite effects on the acquisition of the inflammatory and immunogenic functions of human dendritic cells and macrophages; 3) the determination of the gene signature of human macrophages generated in vitro and isolated ex vivo; 4)  the identification of gene markers specifically expressed by human anti-inflammatory macrophages under physiological and pathological settings (HO-1, FOLR2, CD209, CCL2, HTR2B), and their potential usefulness as therapeutic tools; 5) the demonstration that activin A and Serotonin control the functional polarization of human macrophages.

The group has led the Network “ARTRITIS REUMATOIDE: MECANISMOS FISIOPATOLÓGICOS E IDENTIFICACIÓN DE POSIBLES DIANAS TERRAPEÚTICAS“ (RAPHYME) since 2012, and belongs to ISCIII-funded RETICS “Red de Investigación en Enfermedades Reumáticas” (RIERI) since 2012. The group has been funded by consecutive projects from competitive calls from MCYT/MICIIN/MINECO since 1990, and has also led projects funded by FIS, Comunidad de Madrid, private foundations (Mutua Madrileña, FIPSE, Fundación TV3 La Marató) and major projects from Genoma España (MEICA project). Reagents generated during the research activity of the group have been transferred to the productive sector (monoclonal antibodies against DC-SIGN and LSECtin licensed to Santa Cruz Biotechnology and Serotec).

 

Cuevas VD, Anta L, Samaniego R, Orta-Zavalza E, Vladimir de la Rosa J, Baujat G, Domínguez-Soto Á, Sánchez-Mateos P, Escribese MM, Castrillo A, Cormier-Daire V, Vega MA, Corbí ÁL.
 [2017]. 
MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis. J Immunol. 2017 Mar 1;198(5):2070-2081

 

Funding

1.- Dendritic cell differentiation: Role of cell adhesion in dendritic cellspecific transcription and analysis of expression and functional activities of DC-SIGN (CICYT, SAF2002-04615-C02-01, 2003-2006).

2.- Structural and Functional variability of DC-SIGN: Correlation with susceptibility to HIV and M. tuberculosis infection (FIPSE 36422/03). (FIPSE, 2004-2007).

3.- Effects of probiotics and biogenic amines on the phenotypic and functional properties of human dendritic cells and macrophages (CICYT, AGL2004-02148, 2004-2007; BIAMFOOD UE project, 7th Framework prog. 2007-2010).

4.- Gene expression profiling during differentiation and maturation of human dendritic cells (CICYT, GEN2003-20649-CO6-01, 2004-2007).

5.- DC-SIGN: A pathogen receptor involved in immunesurveillance (CAM, GR/SAL/0638/2004, 2005).

6.- Diferenciación y maduración de células dendríticas: Implicación de los factores de transcripción RUNX3 y PU.1, y actividades funcionales de DC-SIGN que determinan la susceptibilidad a la infección por HIV y otros patógenos (SAF2005-00021)

7.- Base molecular de la actividad pro-oncogénica y supresora de tumores del regulador transcripcional RUNX3 (Mutua Madrileña Automovilista)

8.- Activación de macrófagos: Identificación de moléculas implicadas en la adquisición de funciones efectoras proinflamatorias y anti-inflamatorias (BFU2008-01493).

9.- Molecular and cellular mechanisms in chronic inflammatory and autoinmmune diseases (MEICA project, 2009-2011).

10.- Análisis de los factores del sistema inmunitario innato implicados en la respuesta a la infección por el virus Influenza A (N1H1) V2009 (FIS, GR09/0013).

11.- Expression and function of polysialic acid on dendritic cells (FIS, PI07/0887, 2008-2010)

12.- Characterization of neuropilin-2 and the polysialyltransferase ST8SiaIV as potential therapeutic targets for control if immunity and cancer (FIS, PI10/00304, 2011-2013)

13.- Mecanismos moleculares de la polarización pro- y anti-inflamatoria de macrófagos humanos (SAF2011-23801)

14.- Artritis reumatoide: mecanismos fisiopatológicos e identificación de posibles dianas terapéuticas (S2010/BMD-2350, RAPHYME)

15.- Modulatory actions of Activin A and Serotonin on macrophage activation and inflammatory pathologies (SAF2014-52423-R)

16.- Selective targeting of inflammatory functions of fat-activated macrophages for the treatment of obesity-associated type-2 diabetes (Fundación TV3/ La Marató 22/C/2016)

 

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