Group Leader/s

Head of lab
 

intro

Our laboratory is interested in understanding how macromolecular machines control the flow of genetic information and modulate genome integrity. One of our research aims is to investigate the molecular mechanisms that regulate horizontal gene transfer. Transposable elements often depend on the assembly of large and dynamic multisubunit complexes to prevent spurious double-strand breaks and promote efficient DNA transposition. Our group combines cryo-electron microscopy, x-ray crystallography, together with biochemical and functional assays, to develop atomic-level models to explain how these elements disseminate antibiotic resistance genes, modify gene expression, and generate genomic instability.  

 

Artistic representation of macromolecular machines implicated in DNA transposition.

 

 

Research lines

 

Members

Staff Scientists
Ernesto Arias Palomo
Postdoctorals
Lidia Araujo Bazan
Visitors
Veronica Barea Ullate
Team members
 
 

Funding

- MolSwitch - Análisis estructural y funcional de interruptores macromoleculares implicados en transmisión genética horizontal y diseminación de resistencia a antibióticos. PID2020-120275GB-I00 financiado por MCIN/AEI/10.13039/501100011033. 01/09/2021 - 31/08/2024.

- Crio-microscopio electrónico de transmisión para el estudio de sistemas biológicos. Adquisición de Equipamiento Científico-Técnico 2021. EQC2021-006930-P financiado por MCIN/AEI/10.13039/501100011033 y por la Unión Europea "NextGenerationEU"/ "PRTR". 01/06/2021 - 31/12/2023.

- Unraveling the molecular and structural mechanisms of ATP-dependent transposition. BFU2017-89143-P. MINECO. 2018-2020.

- “Subvenciones a la contratación de doctores por centros de I+D. Ramón y Cajal 2015”. Spanish Ministry of Economy and Competitiveness (MINECO).

 

 

 

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