Description

Dynamic combinatorial chemistry (DCC) studies mixtures of compounds formed through reversible reactions and the response of those mixtures to external stimuli. We work with Protein-directed DCC systems as a hit identification tool in drug discovery searching for modulators of proteins and Protein-protein complexes. We study as well the reversible chemical processes and adapt them to work efficiently under physiological conditions even at low temperatures.                                                                          
In Protein-directed DCC the molecular recognition process takes place in a thermodynamic controlled Dynamic Combinatorial Library (DCL) able to adapt and self-correct the bonds between the different components in the presence of a protein template. If one or more molecules present in the mixture bind to it, yielding a more stable complex, the equilibrium will be displaced to amplify the amount of this compound at the expense of other non-binding constituents (Figure 1).

DCC system
                                  Fig 1. Protein-directed DCC general scheme.

 

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