Group Leader/s



Our group is engaged in a research project aimed at evaluating the potential contribution of cell cycle control failure to neurodegeneration in Alzheimer’s disease and other dementias, as well as in other neurodegenerative disorders such as Amiotrophic Lateral Sclerosis or Parkinson disease. The innovative aspect of their work is to consider non-neuronal cells from patients, as suitable model to study cell proliferation and apoptosis events associated with neurodegenerative pathogenesis. In addition neuronal cultures and murine models are used as experimental models.


Vaca G, Martinez-Gonzalez L, Fernandez A, Rojas-Prats E, Porras G, Cuevas EP, Gil C, Martinez A,Martin-Requero Á.  [2020]. Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) J. Neurochem. doi: 10.1111/jnc.15118



SAF2007-6245: Molecular interactions between Ca2+/Calmodulin and the cell survival/death signaling pathways in non-neuronal cells from patients suffering from Azheimer’ disease and other dementias.

Fundación Eugenio Rodríguez Pascual (2009-2010): Control of cell proliferation and apoptosis in Alzheimer’s disease. Studies in non-neuronal cells from patients and in Tg APP/PS1 mice.

SAF210-15700: Role of Progranulin on the mechanisms of regulation of cell survival/death in the frontotemporal lobar degeneration.

SAF2011-28630: Molecular neurodegenerative mechanisms in the frontotemporal lobar degeneration (FTLD-TDP): Progranulin deficit, cell cycle dysfunction and TDP-43 accumulation (2012-2015)

CIBERER Proyecto Intramural PIBER 3 (Ref #11-734/11202 (2011)

Fundación Ramón Areces XVI Concurso nacional:

Mecanismos moleculares, modelos experimentales y aproximaciones terapéuticas en la Demencia Lobar Frontotemporal (DLFT-TDP)


CTQ2015-66313-R: Quimio-computación en el descubrimiento de rármacos multidiana para el tratamientode la enfermedad de Alzheimer



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