Francisco J Blanco obtained his Ph.D. in Chemistry at the Complutense University of Madrid in 1992. As a predoc at IEM-CSIC, he used NMR for the characterization of linear peptides folding into β-hairpins. As a postdoc at EMBL, he studied the structure and folding of spectrin SH3 domain, and at NIH he used solid-state NMR to study the structure of HIV-Rev protein fibers. He moved back to CSIC in 2000 and participated in a structural genomics project determining the structure of a protein with a novel fold. He joined the CNIO in 2002 as a Ramón y Cajal researcher where he studied tumor suppressor ING4 and several meganucleases. In 2007 he moved to CIC bioGUNE as IKERBASQUE Research Professor to work on the structure-function of proteins relevant to cancer using NMR and other methods, until 2020 when he relocated his lab to CIB-CSIC. He has authored 125 publications with more than 5600 citations, and an h-index of 42. He has supervised 9 Ph.D. Thesis, and is an Honorary Professor of the Universidad Autónoma de Madrid.
O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, OA Mandrup, A Erce-Llamazares, R Lázaro-Gorines, D Nehme-Álvarez, C Domínguez-Alonso, SL Harwood, C Alfonso, B Blanco, L Rubio-Pérez, A Jiménez-Reinoso, L Díez-Alonso, FJ Blanco, L Sanz, KA Howard, L Álvarez-Vallina . A tumor target-dependent 4-1BB agonist antibody fused to albumin engineered for enhanced FcRn binding induces anti-tumor immunity without toxicity. iScience 25, 104958.
B Chaves-Arquero, C Persson, N Merino, J Tomás-Cortazar, AL Rojas, J Anguita, FJ Blanco . Structural Analysis of the Black-Legged Tick Saliva Protein Salp15. International Journal of Molecular Sciences. 23, 3134.
Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L . Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology. 11:2034355.
Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L . An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity. Clin Cancer Res 27, 3167-3177.
Romero JA, Nawrocka EK, Shchukina A, Blanco FJ, Diercks T, Kazimierczuk K . Non‐Stationary Complementary Non‐Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data. Angew Chem Int Ed Engl 132, 23702.
Bruzzone C, Loizaga-Iriarte A, Sánchez-Mosquera P, Gil-Redondo R, Astobiza I, Diercks T, Cortazar AR, Ugalde-Olano A, Schäfer H, Blanco FJ, Unda M, Cannet C, Spraul M, Mato JM, Embade N, Carracedo A, Millet O. . 1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer. J Proteome Res 19, 2419-2428.
González-Magaña A, Blanco FJ. . Human PCNA Structure, Function and Interactions. Biomolecules 10, 570
Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A. . Structure of the processive human Pol δ holoenzyme. Nature Commun 11, 1109
Palacios A, Blanco FJ . Macromolecular crowding increases the affinity of the PHD of ING4 for the histone H3K4me3 mark. Biomolecules 10, 234
González-Magaña A, de Opakua AI, Merino N, Monteiro H, Diercks T, Murciano-Calles J, Luque I, Bernadó P, Cordeiro TN, Biasio A, Blanco FJ. . Double Monoubiquitination Modifies the Molecular Recognition Properties of p15(PAF) Promoting Binding to the Reader Module of Dnmt1. ACS Chem Biol 14, 2315-2326.
Molecular recognition in DNA replication, PID2020-113225GB-I00
Targeting of non-canonical G protein signaling with small molecules, NIH 5R01GM130120-02