RMN Biomolecular | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Head of lab

Francisco Jose Blanco Gutierrez

Ver Proyectos actuales Ver Proyectos anteriores

Molecular recognition in DNA replication and repair

Structure-function of ING tumor suppressors

Targeting non-GPCR regulation of G proteins to stop cancer

Personal Científico
Francisco Jose Blanco Gutierrez

Técnicos
Miriam Barbera Sanchez

Predoctorales
Antonio Ruiz Albor
Mariola Ferreras Gutierrez

Visitantes
Roger Canals Torreguitart

Group

Ruiz-Albor, Antonio, Chaves-Arquero, Belén, Martín-Barros, Inés, Guerra-Castellano, Alejandra, Gonzalez-Magaña, Amaia, de Opakua, Alain Ibáñez, Merino, Nekane, Ferreras-Gutiérrez, Mariola, Berra, Edurne, Díaz-Moreno, Irene, Blanco, Francisco J [2024]. PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation. Int J Biol Macromol 273:133187.

Lázaro-Gorines R, Pérez P, Heras-Murillo I, Adán-Barrientos I, Albericio G, Astorgano D, Flores S, Luczkowiak J, Labiod N, Harwood SL, Segura-Tudela A, Rubio-Pérez L, Nugraha Y, Shang X, Li Y, Alfonso C, Adipietro KA, Abeyawardhane DL, Navarro R, Compte M, Yu W, MacKerell AD Jr, Sanz L, Weber DJ, Blanco FJ, Esteban M, Pozharski E, Godoy-Ruiz R, Muñoz IG, Delgado R, Sancho D, García-Arriaza J, Álvarez-Vallina L [2023]. Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2. Adv Sci, e2304818.

Ferreras-Gutiérrez M, Chaves-Arquero B, González-Magaña M, Merino N, Amusategui-Mateu I, Huecas S, Medrano FJ, Blanco FJ [2023]. Structural analysis of ING3 protein and histone H3 binding. Int J Biol Macromol 242:124724.

Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina. [2023]. A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology 12, 1.

Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J. Blanco, and Mikel Garcia-Marcos. [2023]. Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. Proc Natl Acad Sci USA 120, e2213140120.

Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG [2023]. Molecular insight into the PCNA-binding mode of FBH1. Structure 31, 1-7.

Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM [2023]. Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Biomedicines 11, 337.

O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, OA Mandrup, A Erce-Llamazares, R Lázaro-Gorines, D Nehme-Álvarez, C Domínguez-Alonso, SL Harwood, C Alfonso, B Blanco, L Rubio-Pérez, A Jiménez-Reinoso, L Díez-Alonso, FJ Blanco, L Sanz, KA Howard, L Álvarez-Vallina [2022]. A tumor target-dependent 4-1BB agonist antibody fused to albumin engineered for enhanced FcRn binding induces anti-tumor immunity without toxicity. iScience 25, 104958.

B Chaves-Arquero, C Persson, N Merino, J Tomás-Cortazar, AL Rojas, J Anguita, FJ Blanco [2022]. Structural Analysis of the Black-Legged Tick Saliva Protein Salp15. Int J Mol Sci 23, 3134.

Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L [2022]. Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology 11, 2034355.

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