Description
The lipid composition of neuronal membrane is crucial in regulating
the ion gradients and the neurotransmission across membranes. During these events, the lipid composition changes so as to modulate the properties and the functions of the proteins embedded within the membrane. To facilitate these changes, key regulatory enzymes converge at cellular domains which act as functional platforms for the regulation of the cellular metabolism. One such regulatory platform consists of endoplasmic reticulum (ER)-membranes associated with mitochondria, or MAMs, which are responsible for communication between ER and mitochondria in regulating metabolic changes.
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