Description
To study myeloid-specific transcription, our laboratory is currently determining the gene expression profiles of myeloid cells at distinct differentiation and activation states. In this specific area our efforts are mainly devoted to the identification of genes differentially expressed in pro-inflammatory and anti-inflammatory human macrophages, as a mean to generate diagnostic and therapeutic tools for chronic inflammatory pathologies.
Gene expression signatures of in vitro-generated and ex vivo-isolated human macrophages are being determined also with the aim of defining biological processes, intracellular signaling pathways and transcriptional networks that ultimately determine their inflammatory and immune functions. One additional goal is to identify "predictor" genes that might be useful for the phenotypic characterization of the most relevant myeloid cell subsets present in different tissues and in inflammation-based pathologies.
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