Publications | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Bauer, M. S., Gruber, S., Hausch, A., Gomes, Psfc, Milles, L. F., Nicolaus, T., Schendel, L. C., Navajas, P. L., Procko, E., Lietha, D., Melo, M. C. R., Bernardi, R. C., Gaub, H. E., Lipfert, J. [2022]. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions. Proc Natl Acad Sci U S A. 119:e2114397119-.

Le Coq, J., Acebron, I., Rodrigo Martin, B., Lopez Navajas, P., Lietha, D. [2022]. New insights into FAK structure and function in focal adhesions. J Cell Sci. 135:jcs259089-.

Nozal, V., Martinez-Gonzalez, L., Gomez-Almeria, M., Gonzalo-Consuegra, C., Santana, P., Chaikuad, A., Perez-Cuevas, E., Knapp, S., Lietha, D., Ramirez, D., Petralla, S., Monti, B., Gil, C., Martin-Requero, A., Palomo, V., de Lago, E., Martinez, A. [2022]. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 65:1585-1607-.

Temps, C., Lietha, D., Webb, E. R., Li, X. F., Dawson, J. C., Muir, M., Macleod, K. G., Valero, T., Munro, A. F., Contreras-Montoya, R., Luque-Ortega, J. R., Fraser, C., Beetham, H., Schoenherr, C., Lopalco, M., Arends, M. J., Frame, M. C., Qian, B. Z., Brunton, V. G., Carragher, N. O., Unciti-Broceta, A. [2021]. A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability. Cancer Res. 81:5438-5450-.

Takahashi, K., Kanerva, K., Vanharanta, L., Almeida-Souza, L., Lietha, D., Olkkonen, V. M., Ikonen, E. [2021]. ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange. EMBO J. 40:e106871-.

Le Coq, J., Lopez Navajas, P., Rodrigo Martin, B., Alfonso, C., Lietha, D. [2021]. A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2. FASEB J. 35:e21815-.

Li, B., Li, Y., Tomkiewicz-Raulet, C., Dao, P., Lietha, D., Yen-Pon, E., Du, Z., Coumoul, X., Garbay, C., Etheve-Quelquejeu, M., Chen, H. [2020]. Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma. J Med Chem. 63(21):12707-12724

Acebron, I., Righetto, R. D., Schoenherr, C., de Buhr, S., Redondo, P., Culley, J., Rodriguez, C. F., Daday, C., Biyani, N., Llorca, O., Byron, A., Chami, M., Grater, F., Boskovic, J., Frame, M. C., Stahlberg, H., Lietha, D. [2020]. Structural basis of Focal Adhesion Kinase activation on lipid membranes. EMBO J. 39:e104743-.

Lietha, D., Izard, T. [2020]. Roles of Membrane Domains in Integrin-Mediated Cell Adhesion. Int J Mol Sci. 21(15):5531.

Dawson, J. C., Serrels, B., Byron, A., Muir, M. T., Makda, A., Garcia-Munoz, A., von Kriegsheim, A., Lietha, D., Carragher, N. O., Frame, M. C. [2020]. A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen. Mol Cancer Ther. 19:637-649-.

Tapial Martinez, P., Lopez Navajas, P., Lietha, D. [2020]. FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions. Biomolecules. 10(2):179

Bauer, M. S., Baumann, F., Daday, C., Redondo, P., Durner, E., Jobst, M. A., Milles, L. F., Mercadante, D., Pippig, D. A., Gaub, H. E., Grater, F., Lietha, D. [2019]. Structural and mechanistic insights into mechanoactivation of focal adhesion kinase. Proc Natl Acad Sci U S A. 116:6766-6774-.

Toledo, R. A., Garralda, E., Mitsi, M., Pons, T., Monsech, J., Vega, E., Otero, A., Albarran, M. I., Banos, N., Duran, Y., Bonilla, V., Sarno, F., Camacho-Artacho, M., Sanchez-Perez, T., Perea, S., Alvarez, R., De Martino, A., Lietha, D., Blanco-Aparicio, C., Cubillo, A., Dominguez, O., Martinez-Torrecuadrada, J. L., Hidalgo, M. [2018]. Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. Clin Cancer Res. 24:3550-3559-.

Le Coq, J., Camacho-Artacho, M., Velazquez, J. V., Santiveri, C. M., Gallego, L. H., Campos-Olivas, R., Dolker, N., Lietha, D. [2017]. Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife. 6:-.

Yen-Pon, E., Li, B., Acebron-Garcia-de-Eulate, M., Tomkiewicz-Raulet, C., Dawson, J., Lietha, D., Frame, M. C., Coumoul, X., Garbay, C., Etheve-Quelquejeu, M., Chen, H. [2018]. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. ACS Chem Biol. 13:2067-2073-.

Dao, P., Lietha, D., Etheve-Quelquejeu, M., Garbay, C., Chen, H. [2017]. Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity. Bioorg Med Chem Lett. 27:1727-1730-.

Lietha, D. [2016]. Forcing FAK into Transcriptional Activity. Structure. 24:1223-1225-.

Le Coq, J., Heredia Gallego, L., Lietha, D. [2016]. Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2. Protein J. 35:225-30-.

Dao, P., Smith, N., Tomkiewicz-Raulet, C., Yen-Pon, E., Camacho-Artacho, M., Lietha, D., Herbeuval, J. P., Coumoul, X., Garbay, C., Chen, H. [2015]. Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity. J Med Chem. 58:237-51-.

Balzano, D., Fawal, M. A., Velazquez, J. V., Santiveri, C. M., Yang, J., Pastor, J., Campos-Olivas, R., Djouder, N., Lietha, D. [2015]. Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses. J Biol Chem. 290:24975-85-.