Group Leader/s



Our group has as main research interest the study of the metabolic and regulatory networks that control the bacterial metabolism of toxic compounds and/or biowaste, many of which are major environmental pollutants. The cell signaling circuits and the cognate resistance mechanisms  involved in the bacterial adaptation to the stress caused by the toxic compounds are also under study. To this end, we carry out classic approaches of physiology, biochemistry and molecular biology, in combination with modern omic techniques and in silico metabolic models, to achieve an integrative and systems biology view. The acquired knowledge is also used to design, through systems metabolic engineering, recombinant microorganisms as biofactories for the conversion of contaminants/waste into added value products. The development of sustainable technologies to fix CO2, and to remove and revalorize contaminants and biowaste is a priority within the framework of a circular bio-economy.



Gómez-Álvarez H., Iturbe P., Rivero-Buceta V., Mines P., Bugg, T.D.H., Nogales, J., Díaz, E.  [2022]. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour. Technol. 346:126638.

Sanz D., Díaz E.  [2022]. Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp. CIB. Environ. Microbiol. 24:4987-5004.

Valderrama, J.A., Gómez-Álvarez H., Martín-Moldes, Z., Berbís M.A., Cañada, F.J., Durante-Rodríguez, G., Díaz, E.  [2019]. A novel redox-sensing histidine kinase that controls carbon catabolite repression in Azoarcus sp. CIB. mBio10(2):e00059-19

Martínez I, Mohamed ME, Rozas D, García JL, Díaz E  [2016]. Engineering synthetic bacterial consortia for enhanced desulfurization and revalorization of oil sulfur compounds. Metab Eng. 35:46-54.

Díaz E, Jiménez JI, Nogales J  [2013]. Aerobic degradation of aromatic compounds. Curr. Opin. Biotechnol. 24: 431-442

Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E  [2008]. Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. Proc Nat Acad Sci USA 105:11329-11334



Funding Agencies

Finished projects

  • EU, QLK3-2000-00170 (2000-2003)
  • CICYT, BIO2000-1076 (2000-2003)
  • CICYT, GEN2001-4698-C05-02 (2003-2005)
  • CAM, 07M/0076/2002 (2003-2004)
  • CICYT, BIO2003-01482 (2004-2006)
  • CICYT, VEM2003-20075-C02-02 (2004-2006)
  • CAM, AMB-259-0505 (2006-2010)
  • CSIC 2004 2 0E 073
  • CICYT, BIO2006-05957 (2006-2009)
  • CICYT, EU-SYSMO, GEN2006-27750-C5-3-E(2007-2010)- CICYT
  • Consolider CSD2007-00005 (2008-2013)
  • CICYT BIO2009-10438 (2009-2013)
  • Aramco Overseas Company BV Contract No. 6600029601 (2012-2014)
  • CICYT BIO2012-39501 (2013-2016)
  • FP7-KBBE 311815 (2012-2016)
  • CSIC 2016 2 0E 093 (2016-2018)
  • MINECO PCIN-2014-113 (2015-2018)
  • Ramón-Areces Fundation (XVII CN) (2015-2018)
  • CICYT BIO2016-79736-R (2017-2019)

Active projects

  • MICINN PID2019-110612RB-I00 (2020-2023)
  • CSIC 2019 20E005 (2019-2021)
  • H2020-NMBP-BIO-2017 (2018-2021)
  • PCI2019-111833-2 (EU CoBiotech) (2020-2023)

More info

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