intro
The Autophagy laboratory is directed by Patricia Boya, Research Scientist at CSIC on temporal leave since August 2022. Patricia Boya is now Professor of Cell Biology at the University of Fribourg in Switzerland (https://www.unifr.ch/med/en/research/group/boya/).
Our lab uses cellular and animal models to understand the roles of autophagy in both physiological and pathological conditions. Autophagy is an essential intracellular degradation pathway that recycles cell components generating new building blocks and energy to maintain cellular homeostasis. Autophagy plays an important role in the response to nutrient starvation; the recycling of damaged organelles and is a survival mechanism under stress conditions.
We are interested in the relationships between autophagy and basic processes such as proliferation, differentiation and cell death to gain insight into development and physiological aging. Moreover, we want to understand the role of autophagy in pathologies such as cancer, neurodegenerative, and other disease conditions. We also seek to identify new therapies that target autophagy by screening for new autophagy-modulating drugs with a view to discovering new treatments for human diseases.
Members
| Elena Sierra Filardi |
| Juan Ignacio Jimenez Loygorri |
| Juan Zapata Muñoz |
| Ariadna Rodriguez Martinez |
Selected Publications
Jiménez-Loygorri JI, Villarejo-Zori B, Viedma-Poyatos Á, Zapata-Muñoz J, Benítez-Fernández R, Frutos-Lisón MD, Tomás-Barberán FA, Espín JC, Area-Gómez E, Gomez-Duran A, Boya P. [2024]. Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging. Nat Commun. 2024 Jan 27;15(1):830. doi: 10.1038/s41467-024-45044-1.
Boya P, Kaarniranta K, Handa JT, Sinha D. [2023]. Lysosomes in retinal health and disease. Trends Neurosci. 2023 Dec;46(12):1067-1082. doi: 10.1016/j.tins.2023.09.006.
Gomez-Sintes R, Xin Q, Jimenez-Loygorri JI, McCabe M, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, Dong S, Reynolds CA, Patel B, de la Villa P, Macian F, Boya P, Gavathiotis E, Cuervo AM. [2022]. Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nat Commun. 2022 Jul 21;13(1):4220. doi: 10.1038/s41467-022-31869-1.
Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Alonso-Gil S, Mariño G, de la Villa P, Fitze PS, Fuentes JM, García-Escudero R, Ferrington DA, Gomez-Sintes R, Boya P. [2023]. Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration. Autophagy. 2023 Mar;19(3):784-804. doi: 10.1080/15548627.2022.2103307.
Jiménez-Loygorri JI, Benítez-Fernández R, Viedma-Poyatos Á, Zapata-Muñoz J, Villarejo-Zori B, Gómez-Sintes R, Boya P. [2023]. Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens. Prog Retin Eye Res. 2023 Sep;96:101205. doi: 10.1016/j.preteyeres.2023.101205.
Orhon I, Rocchi C, Villarejo-Zori B, Serrano Martinez P, Baanstra M, Brouwer U, Boya P, Coppes R, Reggiori F. [2022]. Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal. Autophagy. 2022 Feb;18(2):293-308. doi: 10.1080/15548627.2021.1924036.
Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. [2019]. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019 Aug 9. pii: S1550-4131(19)30383-3. doi: 10.1016/j.cmet.2019.07.010.
Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P. [2017]. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 2017 May 2. doi: 10.15252/embj.201695916.
Boya P, Esteban-Martínez L, Serrano-Puebla A, Gómez-Sintes R, Villarejo-Zori B. [2016]. Autophagy in the eye: Development, degeneration, and aging. Prog Retin Eye Res. 2016 Nov;55:206-245.
Rodríguez-Muela N, Hernández-Pinto AM, Serrano-Puebla A, García-Ledo L, Latorre SH, de la Rosa EJ, Boya P [2014]. Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa. Cell Death Differ. 2014 Dec 12.
Funding
- PGC2018-098557-B-I00, MICINN, 2019-2021, Patricia Boya
- Selphagy Therapeutics, 2019-2021, Patricia Boya
- JIN RTI2018-098990-J-I00, MICINN, Raquel Gomez-Sintes
- Fundación Tatiana Pérez de Guzmán el Bueno. 2018-2021, Patricia Boya
- Redes de la Comunidad de Madrid 2017/BMD-3813. 2018-2022, Patricia Boya
- H2020-MSCA-ITN-2017, DRIVE ITN Network 2017-2021, Patricia Boya
- TRANSAUTOPHAGY, COST Action CA15138 (http://cost-transautophagy.eu/presentation/)
- BFU2015-65623, MINECO 2016-2019, Patricia Boya
- Muscular Dystrophy Association, MDA376743. 2016-2019. Natalia Rodriguez-Muela
- NEAR BFU2015-71869-REDT, CSIC 2015-2017, Patricia Boya (http://autofagia.org/founding-members/)
- i-link0701, CSIC 2017, Patricia Boya and Ana M. Cuervo
- SAF2012-36079, MINECO 2013-2016, Patricia Boya
- CONSOLIDER-Ingenio 2010, CDS2010-00045, MICINN 2011-2016, Enrique de la Rosa, Patricia Boya and CIB-CSIC subgroups
- INNPACTO IPT-010000-2010-48, MICINN 2010-2013, Patricia Boya and WIMASIS S.L.
- SAF2009-08086, MICINN 2009-2012, Patricia Boya
- DSM 2015, Patricia Boya
- Explora INGENIO 2010, BFU2006-26073-E, Ministerio de Educación y Ciencia. 2008, Patricia Boya
- CCG06-CSIC/SAL-0821, Comunidad de Madrid. 2007-2008, Patricia Boya
- BM06-125-1, Fundación "La Caixa". 2006-2009, Patricia Boya
- BFU2006-00508, Ministerio de Educación y Ciencia. 2006-2009, Patricia Boya
- Provital 2013-2016, Patricia Boya
- Prous Institute for Biomedical Research. 2008-2011, Patricia Boya
More info
Nosotras respondemos, consultorio científico semanal en El País:
https://elpais.com/elpais/2019/03/22/ciencia/1553267887_593180.html
Autofagia: cómo nuestras células se reciclan.
Conoce a nuestros científicos SEBBM. Patricia Boya - Enero 2017
http://www.sebbm.es/web/images/AAdocumentos/enero2017_patriciaboya.pdf
¿Por qué la autofagia es esencial para mantener nuestras células sanas?
Revista del Colegio Oficial de Biólogos de Madrid, edición Nº 4, dic. de 2016
http://es.calameo.com/books/0015383152199fffa4deb
Autofagia y reciclaje celular, por Patricia Boya
Especial Premios Nobel 2016. Fundación para el Conocimiento madri+d
https://www.madrimasd.org/uploads/cienciaysociedad/documentos/doc/premios_nobel-2016.pdf
Autofagia: el sistema de reciclaje y defensa celular que tienen todas nuestras células”. Patricia Boya.
Anales de la Real Academia Nacional de Farmacia. Vol. 82, Núm. 4 (2016)
http://www.analesranf.com/index.php/aranf/article/view/1793/1786
One fine day at ESOF. Chavarría T, Boya P.
Boletín de la Sociedad Española de Bioquímica y Biología Molecular. Num 157, septiembre 2008.
Early Neural Cell Death: an overlooked process in neural development. De la Rosa EJ, Gómez-Vicente V, Valenciano AI, Boya P, de Pablo F.
An R Acad Nac Farm. 73:1031-1045, 2007.
ESOF, una iniciativa para acercar la ciencia a la sociedad. Boya P, Suárez T.
Boletín de la Sociedad Española de Bioquímica y Biología Molecular. Num 149, septiembre 2006. http://www.sebbm.com/pdf/149/d02149.pdf
Boya P, Suárez T. Los jóvenes y el futuro de la ciencia. Boletín de la Sociedad Española de Bioquímica y Biología Molecular. Num 149, septiembre 2006.
http://www.sebbm.com/pdf/149/d03149.pdf
Alumni:
- Sandra Alonso Gil (2021-2023)
- Álvaro Viedma Poyatos (2021-2022)
- Rocío Benítez Fernández (2021-2022)
- María Martín Bartolomé (2021-2022)
- Inés Maestro Inarejos (2018-2021)
- Petra Teresak (2018-2021)
- Belén Merás Saiz (2020-2021)
- Patricia Velasco Jurado (2019-2020)
- Adele Reiner, France (2020)
- Claudia Pereira, Portugal (2020)
- Katharina Bell, Germany (2018-2020)
- Natalia Rodríguez Muela (2017-2019)
- Ines Rosignol, Germany (2018-2019)
- Carlos Parra Pérez (2018-2019)
- Ignacio Ramírez Pardo (2017-2018)
- Ana Serrano Puebla (2012-2017)
- Lorena Esteban (2009-2017)
- Esther Seco (2011-2016)
- Katharina Sporbeck, Germany (2016)
- Sergio Rivas (2014-2015)
- Lucía García Ledo (2010-2015)
- Rita Marques, Portugal (2013)
- Marta Mauro (2012-2013)
- Fengjuan Wang, China (2012)
- Kike Iglesias (2010-2012)
- Natalia Rodríguez Muela (2006-2012)
- Marta Fierro (2008-2010)
- Sergio Hernández Latorre (2008-2010)
- María Ángeles Mellén (2005-2010)
- Patricia Vázquez (2007-2008)
Boya Lab en el congreso de la Sociedad Española de Autofagia (SEFAGIA), Cáceres 2020.
https://twitter.com/Autofagia_org/status/1241079195465383937?s=19
Entrevista a Patricia Boya, Presidenta de la Sociedad Espanola de Autofagia, SEFAGIA.
https://www.comunicacioncientifica.info/2020/03/23/mi-trabajo-como-cientifica-es-divertidisimo-me-levanto-cada-dia-con-ganas-preguntandome-que-es-lo-que-voy-a-hacer-hoy/
Interview to our faculty, Patricia Boya.
https://www.novusbio.com/faculty/patricia-boya
Noticias relacionadas con el Premio Nobel de Fisiologia y Medicina 2016.
https://www.rtve.es/noticias/20161003/yoshinori-ohsumi-galardonado-nobel-medicina-2016-descubrir-mecanismo-autofagia/1418300.shtml
https://elpais.com/elpais/2016/10/03/ciencia/1475486879_892946.html
https://www.jano.es/noticia-las-implicaciones-medicina-del-descubrimiento-26766
- SEFAGIA Sociedad Española de Autofagia: http://autofagia.org
- COST Transautophagy: http://cost-transautophagy.eu
- Consorcio ELA-Madrid: http://www.elamadrid.es/index.php/es/
- Inventors: M ª Dolores Pérez-Sala Gozalo, Patricia Boya Tremoleda
Title: Use of a peptide sequence for localization and endi-lysosomal degradation
Application Number: P20082721
Priority Country: Spain
Priority Date: September 25th, 2008
Owner entity: Consejo Superior de Investigaciones Científicas
- Inventors: Esteve J, Plaza JA, Gómez R, de la Rosa E, Suárez T, Vázquez P, Boya P, Nogués C, Barrios L, Ibáñez ME, Llobera M, Rosas E, Sánchez FJ, Marco, MP, González D, Muriano A.
Title: Intracelullar device of study cellular parameters in cells and tissues.
Application Number: P20072623
Priority Country: Spain
Priority Date: October 5th, 2007
Owner entity: Consejo Superior de Investigaciones Científicas
- Inventors: Enrique de la Rosa, Flora de Pablo, Patricia Boya, Silvia Corrochano Sánchez, Pedro de la Villa Polo, Rima Barthoum Tannous, Fátima Bosch Tubert.
Title: Use of proinsulin for the preparation of a neuroprtective pharmaceutic composition containing it and applications of thereof.
Application Number: P20061314
Priority Country: Spain
Priority Date: May 22nd, 2006
Owner entity: Consejo Superior de Investigaciones Científicas
Countries that have extended: PCT/ES2007/070097 21/05/2007.
Company/ies that are exploiting "ProRetina Therapeutics SL", formed in July 2007. Patricia Boya, participant.
