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We are a group of scientists interested in understanding how epigenetic changes drive the nuclear deformability, migration and infiltration of leukaemia cells. We are part of the Department of Molecular Medicine at the Centro de Investigaciones Biológicas Margarita Salas.
Cell migration is central to numerous biological functions in embryogenesis, tissue renewal and immunity. Migration of a cell though tissues requires its interaction with its matrix environment, and recently it has become clear that cell plasticity is critical for this motility through narrow spaces. For that, the cell needs to alter the physical properties of the nucleus, as the major and most rigid organelle in the cell body. Most of these advances link the expression of nuclear components, such as lamins, with cell plasticity; however how epigenetic changes affect cell migration is poorly understood. Epigenetic changes control gene transcription and DNA homeostasis, and some of them have been linked to active migration and motility of certain cancer cells.
Lymphocytes, as the immune cells mediating the adaptative response, require fast migration and recycling to/from immune organs to affected tissues, integrin receptors play an essential role during cell migration. Lymphocyte nuclei become remodeled under 2D shear flow conditions, and in a 3D environment when they traverse vessels and migrate through stroma. We hypothesise that both the composition and mechanical properties of the matrix influence migration via a control on cell nuclei. We therefore aim to test this hypothesis by determining how ECM composition and mechanics control nuclear organisation, and how nuclear composition and chromatin modification influence 3D migration. Our work will provide novel insights on how cell-matrix interactions control normal and tumor lymphocyte migration through tissues, which will impact on future treatments for human diseases and cancer.
Diego Herráez-Aguilar , Elena Madrazo , Horacio López-Menéndez , Manuel Ramírez, Francisco Monroy , Javier Redondo-Muñoz . Multiple particle tracking analysis in isolated nuclei reveals the mechanical phenotype of leukemia cells
Javier Redondo-Muñoz , Angeles García-Pardo , Joaquin Teixidó . Molecular Players in Hematologic Tumor Cell Trafficking
Krajnik A, Brazzo JA 3rd, Vaidyanathan K, Das T, Redondo-Muñoz J, Bae Y. . Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease.
Marcel Dreger, Elena Madrazo , Adam Hurlstone , Javier Redondo-Muñoz . Novel contribution of epigenetic changes to nuclear dynamics
Elena Madrazo , David Ruano , Lorea Abad , Estefanía Alonso-Gómez , Carmen Sánchez-Valdepeñas , África González-Murillo , Manuel Ramírez , Javier Redondo-Muñoz . G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells
Pengbo Wang , Marcel Dreger , Elena Madrazo , Craig J Williams , Rafael Samaniego , Nigel W Hodson, Francisco Monroy, Esther Baena, Paloma Sánchez-Mateos, Adam Hurlstone, Javier Redondo-Muñoz . WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment
Ministerio de Ciencia e Innovación con cofinanciación fondos FEDER (Spain).
Gilead International Scholarship in Hematology and Oncology 2017 (USA).
Beca Leonardo Fundación BBVA 2020 (Spain).
Ms. Elena Madrazo (PhD student)
Ms. Raquel González Novo (PhD student)
Dr. Héctor Zamora Carreras (Postdoc)
Ms. Ana de Lope (PhD student)
Mr. Cándido Ortiz (AECC student)
Ms. Lucía Álvaro Aranda (TFM student)
Ms. Andrea Cordero (Undergraduate student)
Mr. David Acitores (Master student)
Ms. Laura Dalia (Undergraduate student)
Mr. Celso Yáñez (Master student)
Ms. Estefanía Alonso (PhD student)
Ms. Roberta Turner (Undergraduate student)
Dr. Carmen Mata Martín (Postdoc)
Mr. Ander de Blas (Master student)
WORKING WITH US
We are always interested in recruiting talented and motivated people with a strong interest in immunology, leukemia and cell migration fields.
Javier obtained a Leonardo Fellowship from BBVA Foundation. https://www.getafecapital.com/2020/10/el-getafense-y-cientifico-del-csic-javier-redondo-gana-la-beca-leonardo-a-investigadores-y-creadores-culturales
Our paper published in Scientific Reports (2020). https://www.lavanguardia.com/vida/20200428/48792666080/desarrollan-una-tecnica-para-mejorar-el-diagnostico-de-la-leucemia-aguda.html http://tribuna.ucm.es/43/art4102.php#.Xqaa-ZMzYUs
Interview in Libertad FM (by Antonio Armas). https://www.radioenfermedadesraras.com/podcast/mecanobiologia-del-nucleo-y-migracion-de-celulas-tumorales-contaminacion-exter-ref100078243.html
Javier Redondo-Muñoz Gilead International Scholarship Awardee.http://tribuna.ucm.es/200/art2864.php#.XqacPZMzYUs
Interview in RadioX London (2016). https://sruk.org.uk/es/podcast/episodio-6-adn-epigenetica/