The main research focus in the Department of Cellular and Molecular Medicine is the study of the molecular mechanisms involved in human physiopathology.
Several groups in the Department are characterizing the molecular bases of various types of cancer, including stem cells, epithelial neoplasms (melanoma, colon carcinoma) and hematological malignancies (myeloma, leukemia). Other aspects under study are vascular and hemostatic disorders, complement-related pathologies, regulation of immune T cells, cell differentiation and mitochondrial transporters. Members of the Department are also studying the processes involved in development, degeneration and aging, aiming to understand the pathological mechanisms of disorders like retinitis pigmentosa, Lafora or Alzheimer´s diseases. This research pursuits the identification of diagnostic markers and target molecules that will help developing new and efficient therapeutic drugs. The Department has played a major role in the implementation and development of high-throughput technologies such as Genomics, Proteomics or Molecular Pharmacology, now basic tools in Biomedicine and other areas in the Centre. It also encourages collaborations among their members and with other departments in the CIB, which serve to improve the productivity and competitiveness of the Centre. High priority goals are to attract bright young investigators performing pioneering research in Biomedicine. The Department also promotes technology transfer initiatives and translational research through the adequate protection of the scientific results and reagents produced by the individual groups. This has already resulted in the generation of biotechnology spin-offs and represents an added value for the Department, which will continue supporting these initiatives.
grupos de investigación
Catalina Hernández CIB
Ignacio Casal CIB
Instituto de Investigaciones Biomédicas. CSIC
Santiago Rodríguez de Córdoba
Patofisiología de la hipoxia: Mecanismos moleculares implicados en hipertensión pulmonar y carcinoma renal.
Mª José Calzada
Universidad Autónoma de Madrid, Departamento de Medicina Instituto de Investigación Princesa
WIP, an actin-binding protein that controls generation, proliferation and invasiveness of cancer stem cells.
Centro Nacional Biotecnología.
Hospital Universitario Gregorio Marañón-Univ. Complutense.