Group Leader/s Head of lab Annamaria Ruggiano Research lines View Current View Past Members Ramón y Cajal Researcher Annamaria Ruggiano Visitors Rodrigo Casas Torreblanca Selected Publications Lascaux, P., Hoslett, G., Tribble, S., Trugenberger, C., Antičević, I., Otten, C., Torrecilla, I., Koukouravas, S., Zhao, Y., Yang, H., Aljarbou, F., Ruggiano, A., Song, W., Peron, C., Deangeli, G., Domingo, E., Bancroft, J., Carrique, L., Johnson, E., Vendrell, I., Fischer, R., Ng, A.W.T., Ngeow, J., D'Angiolella, V., Raimundo, N., Maughan, T., Popović, M., Milošević, I., Ramadan, K. [2024]. TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival. Cell. 187:5698-5718.e26. Torrecilla, I.#, Ruggiano, A.#, Kiianitsa, K., Aljarbou, F., Lascaux, P., Hoslett, G., Song, W., Maizels, N., Ramadan, K. [2024]. Isolation and detection of DNA–protein crosslinks in mammalian cells. Nucleic Acids Research. 52:525-547. Ruggiano, A., Ramadan, K. [2021]. The Trinity of SPRTN Protease Regulation. Trends in Biochemical Sciences. 46:2-4. Ruggiano, A.#, Vaz, B.#, Kilgas, S., Popović, M., Rodriguez-Berriguete, G., Singh, A.N., Higgins, G.S., Kiltie, A.E., Ramadan, K. [2021]. The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. Cell Reports. 37:-. Ruggiano, A., Ramadan, K. [2021]. DNA–protein crosslink proteases in genome stability. Communications Biology. 4:-. Fielden, J., Wiseman, K., Torrecilla, I., Li, S., Hume, S., Chiang, S.-C., Ruggiano, A., Narayan Singh, A., Freire, R., Hassanieh, S., Domingo, E., Vendrell, I., Fischer, R., Kessler, B.M., Maughan, T.S., El-Khamisy, S.F., Ramadan, K. [2020]. TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Nature Communications. 11:-. Fielden, J.#, Ruggiano, A.#, Popović, M., Ramadan, K. [2018]. DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans. DNA Repair. 71:198-204. All Publications Funding More info Currently no information is available
Lascaux, P., Hoslett, G., Tribble, S., Trugenberger, C., Antičević, I., Otten, C., Torrecilla, I., Koukouravas, S., Zhao, Y., Yang, H., Aljarbou, F., Ruggiano, A., Song, W., Peron, C., Deangeli, G., Domingo, E., Bancroft, J., Carrique, L., Johnson, E., Vendrell, I., Fischer, R., Ng, A.W.T., Ngeow, J., D'Angiolella, V., Raimundo, N., Maughan, T., Popović, M., Milošević, I., Ramadan, K. [2024]. TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival. Cell. 187:5698-5718.e26.
Torrecilla, I.#, Ruggiano, A.#, Kiianitsa, K., Aljarbou, F., Lascaux, P., Hoslett, G., Song, W., Maizels, N., Ramadan, K. [2024]. Isolation and detection of DNA–protein crosslinks in mammalian cells. Nucleic Acids Research. 52:525-547.
Ruggiano, A., Ramadan, K. [2021]. The Trinity of SPRTN Protease Regulation. Trends in Biochemical Sciences. 46:2-4.
Ruggiano, A.#, Vaz, B.#, Kilgas, S., Popović, M., Rodriguez-Berriguete, G., Singh, A.N., Higgins, G.S., Kiltie, A.E., Ramadan, K. [2021]. The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. Cell Reports. 37:-.
Ruggiano, A., Ramadan, K. [2021]. DNA–protein crosslink proteases in genome stability. Communications Biology. 4:-.
Fielden, J., Wiseman, K., Torrecilla, I., Li, S., Hume, S., Chiang, S.-C., Ruggiano, A., Narayan Singh, A., Freire, R., Hassanieh, S., Domingo, E., Vendrell, I., Fischer, R., Kessler, B.M., Maughan, T.S., El-Khamisy, S.F., Ramadan, K. [2020]. TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Nature Communications. 11:-.
Fielden, J.#, Ruggiano, A.#, Popović, M., Ramadan, K. [2018]. DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans. DNA Repair. 71:198-204.
