Publications | Centro de Investigaciones Biológicas Margarita Salas

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Canales, A., Nieto, L., Rodríguez-Salarichs, J., Sánchez-Murcia, P.A., Claire Coderch, C., Cortés-Cabrera, A., Paterson, I., Carlomagno, T., Gago, F., Andreu, J.M., Altmann, K.H. Jiménez-Barbero, J. and Díaz, J.F. [2014]. Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches (2014) ACS Chem. Biol. 9 (4) 1033–1043

Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M, Altmann, K.H., Miller, J.H., Díaz, J.F. and Steinmetz, M.O. [2014]. Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A (2014) Angew. Chem. Int. Ed., 53, 1621-1625

Coderch,C., Tang,Y., Klett, J. Zhang, S.E. Ma, Y.T., Wang, S., Matesanz, R., Pera, B., Canales, A. Jiménez-Barbero, J. Morreale, A, Díaz, J.F., Fang, W.S and Gago, F. [2013]. A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure–activity relationships using comparative binding energy (COMBINE) analysis. (2013) Org. Biomol. Chem. 11, 3046

Field JJ, Calvo E, Northcote P, Miller JH, Altmann KH and Díaz JF [2013]. Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent.

Pera B, Barasoain I, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Díaz JF and Andreu JM [2013]. New interfacial microtubule inhibitors of marine origin with potent antitumor activity and a distinct mechanism. ACS Chemical Biology 8:284-294

Paños J., Díaz-Oltra S, Sánchez-Peris M, García-Pla J, Murga J, Falomir E, Carda M, Redondo-Horcajo M, Díaz JF, Barasoain I and Marco A [2013]. Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring,Org. Biomol. Chem., 2013, 11, 5809- 5826 DOI: 10.1039/c3ob40854j

Alvarez R, Puebla P, Díaz JF, Bento AC, García-Navas R, de la Iglesia-Vicente J, Mollinedo F, Andreu JM, Medarde M, Pelaez R [2013]. Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3‑Substituted Indolephenstatins and Indoleisocombretastatins J Med Chem 56:2813−2827 (DOI: 10.1021/jm3015603)

Carda M, Murga J, Paños J, Angulo-Pachón CA, García-Pla J, Díaz-Oltra S, Marco JA, Trigili C, Redondo-Horcajo M, Díaz JF, Barasoain I [2013]. Synthesis and Biological Evaluation As Microtubule-Active Agents of Several Tetrahydrofuran and Spiroacetal Derivatives. Current Medicinal Chemistry 20:1173-1182

Field JJ, Díaz, JF, Miller JH [2013]. The binding sites of microtubule-stabilizing agents. (2013) Chemistry and Biology 20: 301-315 (DOI: dx.doi.org/10.1016/j.chembiol.2013.01.014)

Maccari G, Mori M, Rodríguez-Salarichs J, Fang WS, Díaz JF and Botta M [2013]. Free Energy Profile and Kinetics. Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules (2013) J. Chem. Theory Comput. 2013, 9, 698−706 DOI: dx.doi.org/10.1021/ct3006612.

Carda M, Murga J, Díaz-Oltra S, García-Pla J, Paños J, Falomir E, Trigili C, Díaz JF, Barasoain I, Marco JA [2013]. Synthesis and Biological Evaluation of α-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity (2013) Eur. J. Org. Chem. 1116-1123 DOI: 10.1002/ejoc.201201283

Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz, JF Altmann, KH and Steinmetz, MO [2013]. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents, Science. 339, (6119) 587-590

Cosentino L, Redondo-Horcajo M, Zhao Y, Santos, AR, Chowdury KF, Vinader V, Abdallah QMA, Abdel-Rahman H, Fournier-Dit-Chabert J, Shnyder S, Loadman PM, Fang WS, Díaz JF, Barasoain I, Burns PA, Pors K [2013]. Synthesis and Biological Evaluation of Colchicine B‑Ring Analogues Tethered with Halogenated Benzyl Moieties. J. Med. Chem. 55 (24), pp 11062–11066. DOI: 10.1021/jm301151t.

Fournier-Dit-Chabert J, Vinader V, Santos AR, Redondo-Horcajo M, Dreneau A, Ramkrishna Basak R, Cosentino L, Marston G, Abdel-Rahman H, Loadman PM, Shnyder SD, Díaz JF, Barasoain I, Falconer RA and Pors K [2012]. Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation Bioorganic & Medicinal Chemistry Letters 22 (2012) 7693–7696, DOI:10.1016/j.bmcl.2012.09.104

Milelli A, Tumiatti V, Micco M, Rosini M, Zuccari G, Raffaghello L, Bianchi G, Pistoia V, Díaz JF, Pera B, Trigili C, Barasoain I, Musetti C, Toniolo M, Sissi C, Alcaro S, Moraca F, Zini M, Stefanelli C and Minarini A [2012]. Structure activity relationships of novel substituted naphthalene diimides as anticancer agents. European Journal of Medicinal Chemistry (http://dx.doi.org/10.1016/j.ejmech.2012.06.045)

Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield S, Singh, AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, Hamel E, Barasoain I, Altman KH, Diaz JF [2012]. Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubules. Chemistry and Biology. 19, 686–698 DOI 10.1016/j.chembiol.2012.05.008

Abad A, López Pérez JL, Del Olmo E, García-Fernández LF, Francesch AM, Trigili C, Barasoain I, Andreu JM, Díaz JF, San Feliciano A [2012]. Synthesis, Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins. J Med Chem (DOI: 10.1021/jm2017573)

Coderch C, Klett J, Morreale A, Díaz JF and Gago F [2012]. Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to beta-Tubulin. ChemMedChem 7:836-843 (DOI:10.1002/cmdc.201200065)

Bennani YL, Gu W, Canales A, Díaz JF, Eustace BK, Hoover RR, Jiménez-Barbero J, Nezami A and Wang T [2012]. Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives. J Med Chem 55:1920-1925 (DOI:10.1021/jm200848t)

Calvo E, Barasoain I, Matesanz R, Pera B, Camafeita E, Pineda O, Hamel E, Vanderwal CD, Andreu JM, López JA and Díaz JF [2012]. Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site. Biochemistry (2012), 51, 329-341 (DOI:10.1021/bi201380p)

Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M, Altmann, K.H., Miller, J.H., Díaz, J.F. and Steinmetz, M.O. [2014]. Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A (2014) Angew. Chem. Int. Ed., 53, 1621-1625

Field JJ, Calvo E, Northcote P, Miller JH, Altmann KH and Díaz JF [2013]. Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent.

Field JJ, Díaz, JF, Miller JH [2013]. The binding sites of microtubule-stabilizing agents. (2013) Chemistry and Biology 20: 301-315 (DOI: dx.doi.org/10.1016/j.chembiol.2013.01.014)

Maccari G, Mori M, Rodríguez-Salarichs J, Fang WS, Díaz JF and Botta M [2013]. Free Energy Profile and Kinetics. Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules (2013) J. Chem. Theory Comput. 2013, 9, 698−706 DOI: dx.doi.org/10.1021/ct3006612.

Carda M, Murga J, Díaz-Oltra S, García-Pla J, Paños J, Falomir E, Trigili C, Díaz JF, Barasoain I, Marco JA [2013]. Synthesis and Biological Evaluation of α-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity (2013) Eur. J. Org. Chem. 1116-1123 DOI: 10.1002/ejoc.201201283

Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz, JF Altmann, KH and Steinmetz, MO [2013]. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents, Science. 339, (6119) 587-590

Abad A, López Pérez JL, Del Olmo E, García-Fernández LF, Francesch AM, Trigili C, Barasoain I, Andreu JM, Díaz JF, San Feliciano A [2012]. Synthesis, Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins. J Med Chem (DOI: 10.1021/jm2017573)

Coderch C, Klett J, Morreale A, Díaz JF and Gago F [2012]. Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to beta-Tubulin. ChemMedChem 7:836-843 (DOI:10.1002/cmdc.201200065)

Bennani YL, Gu W, Canales A, Díaz JF, Eustace BK, Hoover RR, Jime&#769;nez-Barbero J, Nezami A and Wang T [2012]. Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives. J Med Chem 55:1920-1925 (DOI:10.1021/jm200848t)

Calvo E, Barasoain I, Matesanz R, Pera B, Camafeita E, Pineda O, Hamel E, Vanderwal CD, Andreu JM, Lo&#769;pez JA and Díaz JF [2012]. Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site. Biochemistry (2012), 51, 329-341 (DOI:10.1021/bi201380p)

Bennani YL, Gu W, Canales A, Díaz JF, Eustace BK, Hoover RR, Jiménez-Barbero J, Nezami A and Wang T [2012]. Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives. J Med Chem 55:1920-1925 (DOI:10.1021/jm200848t)

Calvo E, Barasoain I, Matesanz R, Pera B, Camafeita E, Pineda O, Hamel E, Vanderwal CD, Andreu JM, López JA and Díaz JF [2012]. Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site. Biochemistry (2012), 51, 329-341 (DOI:10.1021/bi201380p)