Tubulinas y FtsZ: modulación del ensamblaje de proteinas

Ruiz, F.M, Huecas, S., Santos-Aledo, A., Prim, E.A., Andreu, J.M.*, Fernández-Tornero, C.*  [2022]. FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. PLoS Biol. 20:e3001497

Huecas S, Araujo-Bazan L, Ruiz FM, Ruiz-Avila LB, Martinez RF, Escobar-Peña A, Artola M, Vazquez-Villa H, Martin-Fontecha M, Fernandez-Tornero C*, Lopez-Rodriguez ML*, Andreu JM* (2021)  . Targeting the FtsZ allosteric binding site with a novel fluorescence polarization screen, cytological and structural approaches for antibacterial discovery. J. Med, Chem, 64, 5730-5745. doi: 10.1021/acs.jmedchem.0c02207

Huecas S, Canosa-Valls AJ, Araújo-Bazán L, Ruíz FM, Laurents DV, Fernandez-Tornero C*, Andreu JM* (2020)  . Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus. FEBS J, doi:10.1111/febs.15235

Araújo-Bazán L, Huecas S, Valle J, Andreu D, Andreu JM  [2019]. Synthetic developmental regulator MciZ targets FtsZ across Bacillus species and inhibits bacterial division. Molecular Microbiology, 111, 865-980 & cover. doi: 10.1111/mmi.14198

Huecas S, Ramirez-Aportela E, Vergoñós A, Nuñez-Ramirez R, Llorca O, Diaz JF, Juan-Rodriguez D, Oliva M.A., Castellen P, Andreu JM.
 [2017]. Self-organization of FtsZ polymers in solution reveals spacer role of the disordered C-terminal tail. Biophysical J., 113, 1831-1844 & cover. doi: 10.1016/j.bpj.2017.08.046

Artola, M., Ruíz-Avila, L.B., Ramírez-Aportela, E., Martínez, R.F., Araujo-Bazán, L., Vázquez-Villa, H., Martín-Fontecha, M., Oliva, M.A., Martín-Galiano, A.J., Chacón, P., López-Rodríguez, M.L., Andreu, J.M., Huecas, S.  [2017]. The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors. Chemical Science. 8:1525-1534.

Wagstaff J, Tsim M, Oliva MA, García-Sanchez A, Kureisaite-Ciziene D, Andreu JM, Löwe J  [2017]. A polymerisation-associated conformational switch in FtsZ that enables treadmilling. Mbio, 8, e00254-17. doi: 10.1128/mBio.00254-17

Ramírez-Aportela, E., López-Blanco, J.R., Andreu, J.M., Chacón, P.  [2014]. Understanding nucleotide-regulated FtsZ filament dynamics and the monomer assembly switch with large-scale atomistic simulations. Biophysical Journal. 107:2164-2176.

Ruiz-Avila, L.B., Huecas, S., Artola, M., Vergoñós, A., Ramírez-Aportela, E., Cercenado, E., Barasoain, I., Vázquez-Villa, H., Martín-Fontecha, M., Chacón, P., López-Rodríguez, M.L., Andreu, J.M.  [2013]. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ. ACS Chemical Biology. 8:2072-2083.

Pera, B., Barasoain, I., Pantazopoulou, A., Canales, A., Matesanz, R., Rodriguez-Salarichs, J., García-Fernandez, L.F., Moneo, V., Jiménez-Barbero, J., Galmarini, C.M., Cuevas, C., Peñalva, M.A., Díaz, J.F., Andreu, J.M.  [2013]. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chemical Biology. 8:2084-2094.

Oliva, M.A., Martin-Galiano, A.J., Sakaguchi, Y., Andreu, J.M.  [2012]. Tubulin homolog TubZ in a phage-encoded partition system. Proc. Natl. Acad. Sci. USA. 109:7711-7716.

Araújo-Bazán, L., Ruiz-Avila, L.B., Andreu, D., Huecas, S., Andreu, J.M.  [2016]. Cytological profile of antibacterial FtsZ inhibitors and synthetic peptide MciZ. Frontiers in Microbiology. 7:-.

Marcelo F, Huecas S, Ruiz-Ávila LB, Cañada FJ, Perona A, Poveda A, Martín-Santamaría S, Morreale A, Jiménez-Barbero J, Andreu JM  [2013]. Interactions of Bacterial Cell Division Protein FtsZ with C8-Substituted Guanine Nucleotide Inhibitors. A Combined NMR, Biochemical and Molecular Modeling Perspective. J. Am. Chem. Soc., 135(44):16418-28