Group Leader/s
Head of lab
intro
Our research explores the interface between chemical biology, medicinal chemistry and supramolecular chemistry. We use modern analytical techniques to study dynamic combinatorial libraries: dynamic networks of interchanging chemical species. We apply these dynamic networks as a hit-identification tool in drug discovery to gain insight into diseases’ etiology and study the properties derived from the molecular networks in the emerging field of systems chemistry to mimic functions encountered in Nature.
Members
| Ruth Perez Fernandez |
| Miguel Angel Ortega Soret |
| Antonio Aguanell Aramendia |
| Maria Makogianni |
| Jorge Ortega Alonso |
Selected Publications
Canal-Martín, A., Pérez-Fernández, R. [2021]. Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. Nature Communications. 12:-.
Canal-Martín, A., Pérez-Fernández, R. [2020]. Protein-Directed Dynamic Combinatorial Chemistry: An Efficient Strategy in Drug Design. ACS Omega. 5:26307-26315.
Canal-Martín A, Sastre J, Sánchez-Barrena MJ, Canales A, Baldominos S, Pascual N, Martínez-González L, Molero D, Fernández-Valle ME, Sáez E, Blanco-Gabella P, Gómez-Rubio E, Martín-Santamaría S, Sáiz A, Mansilla A, Cañada FJ, Jiménez-Barbero J, Martínez A, Pérez-Fernández R. [2019]. Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library. Nat. Commun. 2019, 10, (1):2798. DOI: 10.1038/s41467-019-10627-w
Funding
ERC Consolidator grant 2023. PI: Dr. Ruth Pérez Fernández. Duration: 2024-2029.
Activation and deactivation of proteins through dynamic combinatorial chemistry. PID2022-142565OB-I00 + FPI. PI: Dr. Ruth Pérez Fernández. Duration: 2023-2025.
Eco-efficient carbon capture and mineralization by dynamic-enzyme boosted approach. TED2021-132094B-I00. PI: Dr. Ruth Pérez Fernández. Duration: 2022-2024.
Protein-guided screening: accelerating drug discovery. PID2019-108587RB-I00. PI: Dr. Ruth Pérez Fernández. Duration: 2019-2023.