Description
RING1 proteins are key core components of Polycomb PRC1 complexes. One of the two subset of complexes, variant PRC1, share subunits RYBP/YAF2, whose functions are hardly characterized. Conditional inactivation of the Ring1B or RYBP loci (both of which are essential for embryonic development) show roles in the hematopoietic compartment as global regulators of cell proliferation during differentiation and expansion of hematopoietic cell lineages (in collaboration with C. Calés, IIB/UAM, Madrid). Recently we have focused on their functions in the immortalization of myeloid progenitors, under normal and neoplastic conditions. As models, ex-vivo expanded wild type and mutant primary cells or their counterparts containing transforming fusion proteins are used as proxies of development of normal and leukemic progenitors.
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