Group Leader/s



We are interested in the study of the function of the Polycomb group (PcG) of genes, an evolutionary conserved system involved in the maintenance of transcriptionally repressed states relevant to cell identity. The products of the PcG genes form multiprotein complexes whose activity in transcriptional control is mediated, at least in part, by the histone modifier activities of some of their subunits. In addition to their function during embryogenesis, Polycomb complexes play roles in adult stem cells relevant to normal tissue regeneration and cancer. The lab is focused on the function of Polycomb complexes containig Ring1A and Ring1B, the E3 ligases involved in monoubiquitylation of histone H2A.


Ikawa,T., Masuda, K., Endo, T.A., Endo,M., Isono, K., Koseki, Y., Nakagawa, R., Kometani, K., Takano,Y., Agata, Y., Katsura, Y., Kurosaki, T.,Vidal, M., Koseki, H. and Kawamoto, H.  [2016]. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes & Dev. 30:2475-2485

Calés C, Pavón L, Starowicz K, Pérez C, Bravo M, Ikawa T, Koseki H and Vidal M.  [2016]. Role of Polycomb RYBP in Maintaining the B-1 to B-2 B-Cell Lineage Switch in Adult Hematopoyesis. Mol. Cell. Biol. 36:900-912



Funding Agencies

Fundación Ramón Areces (2010-2012)

S2010/BMD-2470 (2012-2015)

FP7-PEOPLE-2011-ITN (2012-2015)

SAF2013-47997-P (2013-2016)


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