Description Magnesium and its alloys are biodegradable biomaterials that can be more suitable materials than any other implants for bone repair application due to its biodegrability, reabsorbability and osteoconductivity. Furthermore the density, elastic modulus and compressive strength properties of magnesium are similar to that of natural bone than other materials currently used for endoprosthetic applications. In addition, magnesium is a necessary element for the incorporation of calcium to bone and to stimulate the growth of new tissue, is non-toxic and can be excreted through human metabolism system, making it suitable for orthopedic applications. In spite of the desirable properties that magnesium-based materials have, these materials have a very high corrosion rate in physiological environment that need to be controlled. Our group is involved in a research program that apply different approximations to control the degradation kinetic and design new magnesium-based metallic materials with a controlled reabsorbability synchronized with the repair of the bone tissue. The interaction between the cell and these biodegradable materials and particles derived from them is analyzed by different cellular assays and by proteomic profile to identify those proteins that could be affected by the cell-biomaterial interaction. Members Head: Rosa María Lozano Puerto Group Cell-Biomaterial Recognition