Functions of chemotactic receptors and the immunological synapse in dendritic cells | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Head of lab

José Luis Rodríguez Fernández

Functions of the Dendritic Cells Controled by CCR7 and the Immune Synpase

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Molecular mechanisms used the chemokine receptor CCR7 to regulate the funcions of dendritic cells

Head:

José Luis Rodríguez Fernández

Staff Scientists
José Luis Rodríguez Fernández

Ad Honorem
Carmelo Bernabeu Quirante

Visitors
Carolina María Rodriguez Sanchez
Sergio Llorente Palomo

Team Image

José Luis Rodríguez-Fernández, Olga Criado-García [2022]. A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing. FRONT. IMMUNOL. 13: 1001086

Rodríguez-Fernández JL, Criado-García O. [2021]. The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells. FRONT CELL DEV BIOL. 9: 679500

Rodríguez-Fernández JL, Criado-García O [2020]. Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors. FRONT. IMMUNOL. 11:596902

Rodríguez-Fernández JL, Criado-García O. [2020]. The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells. FRONT. IMMUNOL. 11:528

Gómez-Cabañas L, López-Cotarelo P, Criado-García O, Murphy MP, Boya P, Rodríguez-Fernández JL. [2019]. Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells. J IMMUNOL. 202: 1715-1723

Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. [2018]. Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis. MOL CELL BIOL. 38: e00534-17

Martínez-Muñoz L, Villares R, Rodríguez-Fernández JL, Rodríguez-Frade JM, Mellado M. [2018]. Remodeling our concept of chemokine receptor function: From monomers to oligomers. J LEUKOC BIOL 104:323-331

Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, López-Cotarelo P, Tellechea M, Martínez-Martínez S, Redondo JM, Martín-Caballero J, Flores JM, Bosch E, Rodríguez-Fernández JL, Aramburu J, López-Rodríguez C [2018]. Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5. J. EXP. MED. 215:2901-2918

López-Cotarelo, P. Gómez-Moreira, C, Criado-García O., Sánchez, L and Rodríguez-Fernández, JL [2017]. Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes. TRENDS IMMUNOL. 38, 927-941

Torres-Bacete J, Delgado-Martín C, Gómez-Moreira C, Simizu S, Rodríguez-Fernández JL. [2015]. The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells. J. IMMUNOL. 195: 973-981

All Publications

Grant: PID2020-114147RB-I00.

Agency: Ministerio de Ciencia e Innovación.

Title: Modulación de las funciones de las células dendríticas maduras por el receptor de quimioquinas CCR7 y la sinapsis inmunológica.

Starting and Finish dates: 2021-2024

Currently no information is available