Functions of chemotactic receptors and the immunological synapse in dendritic cells | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Head of lab

José Luis Rodríguez Fernández

Functions of the Dendritic Cells Controled by CCR7 and the Immune Synpase

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Molecular mechanisms used the chemokine receptor CCR7 to regulate the funcions of dendritic cells

Head:

José Luis Rodríguez Fernández

Staff Scientists
José Luis Rodríguez Fernández

Ad Honorem
Carmelo Bernabeu Quirante

Visitors
Carolina María Rodriguez Sanchez
Sergio Llorente Palomo
Ana Maria Arnau Sancho

Team Image

José Luis Rodríguez-Fernández, Olga Criado-García [2022]. A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing. FRONT. IMMUNOL. 13: 1001086

Rodríguez-Fernández JL, Criado-García O. [2021]. The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells. FRONT CELL DEV BIOL. 9: 679500

Rodríguez-Fernández JL, Criado-García O [2020]. Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors. FRONT. IMMUNOL. 11:596902

Rodríguez-Fernández JL, Criado-García O. [2020]. The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells. FRONT. IMMUNOL. 11:528

Gómez-Cabañas L, López-Cotarelo P, Criado-García O, Murphy MP, Boya P, Rodríguez-Fernández JL. [2019]. Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells. J IMMUNOL. 202: 1715-1723

Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. [2018]. Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis. MOL CELL BIOL. 38: e00534-17

Martínez-Muñoz L, Villares R, Rodríguez-Fernández JL, Rodríguez-Frade JM, Mellado M. [2018]. Remodeling our concept of chemokine receptor function: From monomers to oligomers. J LEUKOC BIOL 104:323-331

Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, López-Cotarelo P, Tellechea M, Martínez-Martínez S, Redondo JM, Martín-Caballero J, Flores JM, Bosch E, Rodríguez-Fernández JL, Aramburu J, López-Rodríguez C [2018]. Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5. J. EXP. MED. 215:2901-2918

López-Cotarelo, P. Gómez-Moreira, C, Criado-García O., Sánchez, L and Rodríguez-Fernández, JL [2017]. Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes. TRENDS IMMUNOL. 38, 927-941

Torres-Bacete J, Delgado-Martín C, Gómez-Moreira C, Simizu S, Rodríguez-Fernández JL. [2015]. The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells. J. IMMUNOL. 195: 973-981

All Publications

Grant: PID2020-114147RB-I00.

Agency: Ministerio de Ciencia e Innovación.

Title: Modulación de las funciones de las células dendríticas maduras por el receptor de quimioquinas CCR7 y la sinapsis inmunológica.

Starting and Finish dates: 2021-2024

Currently no information is available