Publications | Centro de Investigaciones Biológicas Margarita Salas

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Pluta, R. Boer, R.D., Lorenzo-Díaz, F. Russi, S. Gómez, H., Fernández-López, C. Perez-Luque, R., Orozco, M., Espinosa, M. and Coll, M. [2017]. Structural basis of a novel histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance. Proc. Natl. Acad. Sci. USA. 114, E6526–E6535. doi: 0.1073/pnas.1702971114.

Díaz-Orejas, R., Espinosa, M. and Yeo, C.C. [2017]. The importance of the expendable: Toxin-Antitoxin genes in plasmids and chromosomes. Front. Microbiol. 8:1479. doi: 10.3389/fmicb.2017.01479.

F. Lorenzo-Díaz, C. Fernández-López, R. Lurz, A. Bravo and M. Espinosa [2017]. Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase. Nucleic Acids Res (2017) 45: 7774-7785. doi: 10.1093/nar/gkx450

Venkova T, Juárez A, Espinosa, M. [2017]. Editorial: Modulating Prokaryotic Lifestyle by DNA-Binding Proteins: Learning from (Apparently) Simple Systems. Front. Mol. Biosci. 3. doi: 10.3389/fmolb.2016.00086.

Chan WT, Moreno-Córdoba I, Espinosa M [2016]. Singh Chhatwal, our friend. Environ. Microbiol. Reports. 8:556-557. doi:10.1111/1758-2229.12464.

Lorenzo-Diaz F, Fernández-Lopez C, Douarre PE, Baez-Ortega A, Flores C, Glaser P, Espinosa M [2016]. Streptococcal Group B integrative and mobilizable Element IMESagrpsI encodes a functional relaxase involved in its transfer. Open Biology 6: 160084. doi: 10.1098/rsob.160084

Solano-Collado V, Hüttener M, Espinosa M, Juárez A, Bravo A [2016]. MgaSpn and H-NS: two unrelated global regulators with similar DNA-binding properties. Front. Mol. Biosci. 3:60. doi: 10.3389/fmolb.2016.00060.

Chan WT, Espinosa M [2016]. The Streptococcus pneumoniae pezAT toxin-antitoxin system reduces β-lactam resistance and genetic competence. Front. Microbiol. 7:1322. doi: 10.3389/fmicb.2016.01322.

Chan WT, Espinosa M, Yeo CC [2016]. Keeping the Wolves at Bay: Antitoxins of Prokaryotic TypeII Toxin-Antitoxin Systems. Front. Mol.Biosci. 3:9. doi: 10.3389/fmolb.2016.00009

Chan WT, Espinosa M. [2016]. The antibacterials that have yet to be found. Atlas of Science, February 24, 2016

Yeo CC, Bakar FA, Chan WT, Espinosa M, Harikrishna JA [2016]. Heterologous expression of toxins from bacterial Toxin-Antitoxin systems in eukaryotic cells: Strategies and applications. Toxins, 8, 49; doi:10.3390/toxins8020049.

Ruiz-Cruz S, Espinosa M, Goldmann O, Bravo A [2016]. Global regulation of gene expression by the MafR protein of Enterococcus faecalis. Front Microbiol 6:1521 (doi: 10.3389/fmicb.2015.01521)

López-Aguilar C, Romero-López C, Espinosa M, Berzal-Herranz A, del Solar G [2015]. The 5′-tail of antisense RNAII of pMV158 plays a critical role in binding to the target mRNA and in translation inhibition of repB. Front. Genet. 6:225. doi: 10.3389/fgene.2015.00225.

Chan WT, Balsa D, Espinosa M [2015]. One cannot rule them all: Are bacterial toxins-antitoxins druggable? FEMS Microbiol. Rev. 39(4): 522-540 doi: 10.1093/femsre/fuv002.

Garcillan-Barcia, MP, Espinosa M [2015]. The antisense leitmotif: A prelude. Plasmid. 78: 1-3.

Ruiz-Masó JA, Machón C, Bordanaba-Ruiseco L, Espinosa M, Coll M del Solar G [2015]. Plasmid rolling circle replication. Microbiol Spectrum 3 (1). doi:10.1128/microbiolspec.PLAS-0035-2014

**Chan WT*, Yeo CC, Sadowy E, Espinosa M [2014].** Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front Microbiol 5:677 (doi: 10.3389/fmicb.2014.00677)

Hernández-Arriaga AM, Chan WT, Espinosa M, Díaz-Orejas R [2014]. Conditional activation of toxin-antitoxin systems: postsegregational killing and beyond. Microbiol Spectrum 2(5): PLAS-0009-2013. doi:10.1128/microbiolspec.PLAS-0009-2013.

Scheb-Wetzel M, Rohde M, Bravo A, Goldmann O [2014]. New insights into the antimicrobial effect of mast cells against Enterococcus faecalis. Infect. Immun. 82: 4496-4507 (doi:10.1128/IAI.02114-14)

Fernández-López C, Bravo A, Ruiz-Cruz, S, Solano-Collado V, Garsin DA, Lorenzo-Díaz F, Espinosa M [2014]. Mobilizable Rolling-Circle Replicating Plasmids from Gram-Positive Bacteria: A Low-Cost Conjugative Transfer. Microbiol Spectrum. 2 (5): PLAS-0008-2013; doi:10.1128/microbiolspec.PLAS-0008-2013.

Díaz-Orejas, R., Espinosa, M. and Yeo, C.C. [2017]. The importance of the expendable: Toxin-Antitoxin genes in plasmids and chromosomes. Front. Microbiol. 8:1479. doi: 10.3389/fmicb.2017.01479.

F. Lorenzo-Díaz, C. Fernández-López, R. Lurz, A. Bravo and M. Espinosa [2017]. Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase. Nucleic Acids Res (2017) 45: 7774-7785. doi: 10.1093/nar/gkx450

Venkova T, Juárez A, Espinosa, M. [2017]. Editorial: Modulating Prokaryotic Lifestyle by DNA-Binding Proteins: Learning from (Apparently) Simple Systems. Front. Mol. Biosci. 3. doi: 10.3389/fmolb.2016.00086.

Chan WT, Moreno-Córdoba I, Espinosa M [2016]. Singh Chhatwal, our friend. Environ. Microbiol. Reports. 8:556-557. doi:10.1111/1758-2229.12464.

Lorenzo-Diaz F, Fernández-Lopez C, Douarre PE, Baez-Ortega A, Flores C, Glaser P, Espinosa M [2016]. Streptococcal Group B integrative and mobilizable Element IMESagrpsI encodes a functional relaxase involved in its transfer. Open Biology 6: 160084. doi: 10.1098/rsob.160084

Solano-Collado V, Hüttener M, Espinosa M, Juárez A, Bravo A [2016]. MgaSpn and H-NS: two unrelated global regulators with similar DNA-binding properties. Front. Mol. Biosci. 3:60. doi: 10.3389/fmolb.2016.00060.

Chan WT, Espinosa M [2016]. The Streptococcus pneumoniae pezAT toxin-antitoxin system reduces β-lactam resistance and genetic competence. Front. Microbiol. 7:1322. doi: 10.3389/fmicb.2016.01322.

Chan WT, Espinosa M, Yeo CC [2016]. Keeping the Wolves at Bay: Antitoxins of Prokaryotic TypeII Toxin-Antitoxin Systems. Front. Mol.Biosci. 3:9. doi: 10.3389/fmolb.2016.00009

Chan WT, Espinosa M. [2016]. The antibacterials that have yet to be found. Atlas of Science, February 24, 2016

Yeo CC, Bakar FA, Chan WT, Espinosa M, Harikrishna JA [2016]. Heterologous expression of toxins from bacterial Toxin-Antitoxin systems in eukaryotic cells: Strategies and applications. Toxins, 8, 49; doi:10.3390/toxins8020049.

Ruiz-Cruz S, Espinosa M, Goldmann O, Bravo A [2016]. Global regulation of gene expression by the MafR protein of Enterococcus faecalis. Front Microbiol 6:1521 (doi: 10.3389/fmicb.2015.01521)

López-Aguilar C, Romero-López C, Espinosa M, Berzal-Herranz A, del Solar G [2015]. The 5′-tail of antisense RNAII of pMV158 plays a critical role in binding to the target mRNA and in translation inhibition of repB. Front. Genet. 6:225. doi: 10.3389/fgene.2015.00225.

Chan WT, Balsa D, Espinosa M [2015]. One cannot rule them all: Are bacterial toxins-antitoxins druggable? FEMS Microbiol. Rev. 39(4): 522-540 doi: 10.1093/femsre/fuv002.

Garcillan-Barcia, MP, Espinosa M [2015]. The antisense leitmotif: A prelude. Plasmid. 78: 1-3.

Ruiz-Masó JA, Machón C, Bordanaba-Ruiseco L, Espinosa M, Coll M del Solar G [2015]. Plasmid rolling circle replication. Microbiol Spectrum 3 (1). doi:10.1128/microbiolspec.PLAS-0035-2014

Chan WT*, Yeo CC, Sadowy E, Espinosa M [2014]. Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front Microbiol 5:677 (doi: 10.3389/fmicb.2014.00677)

Hernández-Arriaga AM, Chan WT, Espinosa M, Díaz-Orejas R [2014]. Conditional activation of toxin-antitoxin systems: postsegregational killing and beyond. Microbiol Spectrum 2(5): PLAS-0009-2013. doi:10.1128/microbiolspec.PLAS-0009-2013.

Scheb-Wetzel M, Rohde M, Bravo A, Goldmann O [2014]. New insights into the antimicrobial effect of mast cells against Enterococcus faecalis. Infect. Immun. 82: 4496-4507 (doi:10.1128/IAI.02114-14)

**Chan WT*, Yeo CC, Sadowy E, Espinosa M [2014].** Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front Microbiol 5:677 (doi: 10.3389/fmicb.2014.00677)